Originalarbeiten

Fritsche E, Haarmann-Stemmann T, Kapr J, Galanjuk S, Hartmann J, Mertens PR, Kämpfer AAM, Schins RPF, Tigges J, Koch K: Stem cells for next level toxicity testing in the 21st century. Small 202006252, 2020. doi: 10.1002/smll.202006252

Ghashghaei O, Pedrola M, Seghetti F, Martin VV, Zavarce R, Babiak M, Novacek J, Hartung F, Rolfes KM, Haarmann-Stemmann T, Lavilla R:  Extended Multicomponent Reactions with Indole Aldehydes. Access to Unprecedented Polyheterocyclic Scaffolds, Ligands of the Aryl Hydrocarbon Receptor. Angew Chem Int Edit, doi: 10.1002/anie.202011253 and 10.1002,10/2020 online.

Busch M, Bredeck G, Kämpfer AAM, Schins RPF. Acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine. Environ Res 2020 Nov 27:110536. doi: 10.1016/j.envres.2020.110536. Online ahead of print.

Merches K, Schiavi A, Weighardt H, Steinwachs S, Teichweyde N, Förster I, Hochrath K, Schumak B, Ventura N, Petzsch P, Köhrer K, Esser C: AHR signaling dampens inflammatory signature in neonatal skin γδ T cells. Int J Mol Sci 21(6): 2249, 2020. doi: 10.3390/ijms21062249

Lademann J, Richter H, Patzelt A, Meinke MC, Gross I, Grether-Beck S, Krutmann J, Frazier L, Darvin ME: Laser scanning microscopy for control of skin decontamination efficacy from airborne particulates using highly absorbent textile nanofiber material in combination with PEG-12 dimethicone. Skin Res Technol 2020. doi: 10.1111/srt.12830

Fritsche E, Tigges J, Hartmann J, Kapr J, Serafini MM, Viviani B: Neural in vitro models for studying substances acting on the central nervous system. Handb Exp Pharmacol 2020 doi: 10.1007/164_367

Trullàs C, Granger C, Lim HW, Krutmann J, Masson P: Linear and exponential sunscreen behaviours as an explanation for observed discrepancies in sun protection factor testing. Photodermatol Photoimmunol Photomed 2020. doi: 10.1111/phpp.12500

Pavez-Lorie E, Stricker N, Plitta-Michalak B, Peng-Chen I, Volkmer B, Greinert R, Jauch A, Boukamp P, Rapp, A: Characterisation of the novel spontaneously immortalized and invasively growing human skin keratinocyte line HaSKpw. Sci Rep 10: 5196, 2020. doi: 10.1038/s41598-020-71315-0

Wahle T, Sofranko A, Dekkers S, Miller MR; Heusinkveld HJ, Albrecht C, Cassee FR, Schins RPF: Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer’s and vascular disease. Neurochem Int 2020. doi: 10.1016/j.neuint.2020.104755

Kämpfer AAM, Busch M, Schins RPF: Advanced in vitro testing strategies and models of the intestine for nanosafety research. Chem Res Toxicol 33(5): 1163-1178, 2020. doi: 10.1021/acs.chemrestox.0c00079

Abramson MJ, Wigmann C, Altug H, Schikowski T: Ambient air pollution is associated with airway inflammation in older women: a nested cross-sectional analysis. BMJ Open Respir Res 7: e000549, 2020. doi: 10.1136/bmjresp-2019-000549

Baswan SM, Marini A, Klosner AE, Jaenicke T, Leverett J, Murray M, Gellenbeck KW, Krutmann J: Orally administered mixed carotenoids protect human skin against ultraviolet A-induced skin pigmentation: A double-blind, placebo-controlled, randomized clinical trial. Photodermatol Photoimmunol Photomed 36(3): 219-225, 2020. doi: 10.1111/phpp.12541

Häselbarth L, Ouwens DM, Teichweyde N, Hochrath K, Merches K, Esser C: The small chain fatty acid butyrate antagonizes the TCR-stimulation-induced metabolic shift in murine epidermal gamma delta T cells. EXCLI J 19: 334-350, 2020. doi: 10.17179/excli2020-1123

Madhusudhan N, Pausan MR, Halwachs B, Durdević M, Windisch M, Kehrmann J, Patra V, Wolf P, Boukamp P, Moissl-Eichinger C, Cerroni L, Becker JC, Gorkiewicz G: Molecular profiling of keratinocyte skin tumors links Staphylococcus aureus overabundance and increased human β-Defensin-2 expression to growth promotion of squamous cell carcinoma. Cancers (Basel) 12(3): 541, 2020. doi: 10.3390/cancers12030541

Boots AW,  Veith C, Albrecht C, Bartholome R, Drittij MJ, Claessen SMH, Bast A, Rosenbruch M, Jonkers L, van Schooten FJ, Schins RPF: The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice. BMC Pulm Med 20: 112, 2020. doi: 10.1186/s12890-020-1142-x

Nimtz L, Hartmann J, Tigges J, Masjosthusmann S, Schmuck M, Keßel E, Theiss S, Köhrer K, Petzsch P, Adjaye J, Wigmann C, Wieczorek D, Hildebrandt B, Bendt F, Hübenthal U, Brockerhoff G, Fritsche E: Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation. Stem Cell Res 45: 101761, 2020. doi: 10.1016/j.scr.2020.101761

Pavez Loriè E, Boukamp P: Methods in cell biology: Cell-derived matrices. Methods Cell Biol 156: 309-332, 2020. doi: 10.1016/bs.mcb.2019.11.012

Merches K, Schiavi A, Weighardt H, Steinwachs S, Teichweyde N, Förster I, Hochrath K, Schumak B, Ventura N, Petzsch P, Köhrer K, Esser C: AHR signaling dampens inflammatory signature in neonatal skin γδ T cells. Int J Mol Sci 21(6): 2249, 2020. doi: 10.3390/ijms21062249

Wang Q, Zhao Q, Wang G, Wang B, Zhang Y, Zhang J, Li N, Zhao Y, Qiao H, Li W, Liu X, Liu L, Wang F, Zhang Y, Guo Y: The association between ambient temperature and clinical visits for inflammation-related diseases in rural areas in China. Environ Pollut 261: 114128, 2020. doi: 10.1016/j.envpol.2020.114128

Schikowski T*, Wigmann C*, Fuks KB*, et al.: Blutdruckmessung in der NAKO – methodische Unterschiede, Blutdruckverteilung und Bekanntheit der Hypertonie im Vergleich zu anderen bevölkerungsbezogenen Studien in Deutschland. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63(4): 452-464, 2020. doi: 10.1007/s00103-020-03109-8 (* equal contribution)

weitere Beiträge zur NAKO im Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz:

March 2020, issue 3: Die Basiserhebung der NAKO Gesundheitsstudie – Teil I: Erste Ergebnisse zu sozialen und medizinischen Faktoren

April 2020, issue 4: Die Basiserhebung der NAKO Gesundheitsstudie – Teil II: Erste Ergebnisse zu häufigen Volkskrankheiten

Altuğ H, Fuks KB, Hüls A, Mayer AK, Tham R, Krutmann J, Schikowski T: Air pollution is associated with depressive symptoms in elderly women with cognitive impairment. Environ Int 136: 105448, 2020. doi: 10.1016/j.envint.2019.105448

Tan Y, Wang F, Fan G, Yan Z, Li B, Li N, Liu Y, Wang X, Liu W, Krutmann J, Zou Y, Wang S: Identification of factors associated with minimal erythema dose (MED) variations in a large-scale population study of 22,146 subjects. J Eur Acad Dermatol Venereol 2020. doi: 10.1111/jdv.16206

Lademann J, Richter H, Patzelt A, Meinke MC, Gross I, Grether-Beck S, Krutmann J, Frazier L, Darvin ME: Laser scanning microscopy for control of skin decontamination efficacy from airborne particulates using highly absorbent textile nanofiber material in combination with PEG-12 dimethicone. Skin Res Technol 2020. doi: 10.1111/srt.12830

Uhlmann C, Kuhn LM, Tigges J, Fritsche E, Kahlert DU: Efficient modulation of TP53 expression in human induced pluripotent stem cells. Curr Protoc Stem Cell Biol 52(1): e102, 2020. doi: 10.1002/cpsc.102

Thyssen JP, Ahluwalia TS, Paternoster L, Ballardini N, Bergström A, Melén E, Chawes B, Stokholm J, Hourihane JO, O'Sullivan DM, Bager P, Maelbye M, Bustamante M, Torrent M, Esplugues A, Duijts L, Hu C, Elbert NJ, Pasmans SGMA, Nijsten TEC, von Berg A, Standl M, Schikowski T, Herberth G, Heinrich J, Lee YA, Marenholz I, Lau S, Curtin JA, Simpson A, Custovic A, Pennell CE, Wang CA, Holt PG, Bisgaard H, Bønnelykke K: Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis. Allergy 75(6): 1481-1485, 2020. doi: 10.1111/all.14162

Mekic S, Hamer MA, Wigmann C, Gunn DA, Kayser M, Jacobs LC, Schikowski T, Nijsten T, Pardo LM: Epidemiology and determinants of facial telangiectasia: a cross-sectional study. J Eur Acad Dermatol Venereol 34(4): 821-826, 2020. doi: 10.1111/jdv.15996

Grether-Beck S, Marini A, Jaenicke T, Goessens-Rück P, McElwee KJ, Hoffmann R, Krutmann J: Autologous cell therapy for aged human skin: a randomized, placebo-controlled, phase-I study. Skin Pharmacol Physiol 33: 9-16, 2020. doi: 10.1159/000502240

Trullàs C, Granger C, Lim HW, Krutmann J, Masson P: Linear and exponential sunscreen behaviours as an explanation for observed discrepancies in sun protection factor testing. Photodermatol Photoimmunol Photomed 2020. doi: 10.1111/phpp.12500

Übersichtsarbeiten, Buchbeiträge u.a.

Esser C, Hochrath K, Schikowski T, Haarmann-Stemmann T: COVID-19 research: toxicological input urgently needed! Arch Toxicol 2020. doi: 10.1007/s00204-020-02803-5

Lupu D, Andersson P, Bornehag CG, Demeneix B, Fritsche E, Gennings C, Lichtensteiger W, Leist M, Leonards PEG, Ponsonby AL, Scholze M, Testa G, Tresguerres JAF, Westerink RHS, Zalc B, Rüegg J: The ENDpoiNTs project: Novel testing strategies for endocrine disruptors linked to developmental neurotoxicity. Int J Mol Sci 21: 3978, 2020. doi: 10.3390/ijms21113978

Bernhard GH, Neale RE, Barnes PW, Neale PJ, Zepp RG, Wilson SR, Andrady AL, Bais AF, McKenzie RL, Aucamp PJ, Young PJ, Liley JB, Lucas RM, Yazar S, Rhodes LE, Byrne SN, Hollestein LM, Olsen CM, Young AR, Robson TM, Bornman JF, Jansen MAK, Robinson SA, Ballaré CL, Williamson CE, Rose KC, Banaszak AT, Häder DP, Hylander S, Wängberg SÅ, Austin AT, Hou WC, Paul ND, Madronich S, Sulzberger B, Solomon KR, Li H, Schikowski T, Longstreth J, Pandey KK, Heikkilä AM, White CC: Environmental effects of stratospheric ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2019. Photochem Photobiol Sci 19(5): 542-584, 2020. doi: 10.1039/d0pp90011g

Thurston GD, Balmes JR, Garcia E, Gilliland FD, Rice MB, Schikowski T, Van Winkle LS, Annesi-Maesano I, Burchard EG, Carlsten C, Harkema JR, Khreis H, Kleeberger SR, Kodavanti UP, London SJ, McConnell R, Peden DB, Pinkerton KE, Reibman J, White CW: Outdoor air pollution and new-onset airway disease. An official American Thoracic Society workshop report. Ann Am Thorac Soc 17(4): 387-398, 2020. doi: 10.1513/AnnalsATS.202001-046ST

Schiavi A, Strappazzon F, Ventura N: Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies. Mech Ageing Dev 188: 111252, 2020. doi: 10.1016/j.mad.2020.111252

Vogel CFA, Van Winkle LS, Esser C, Haarmann-Stemmann T: The aryl hydrocarbon receptor as a target of environmental stressors – implications for pollution-mediated stress and inflammatory responses. Redox Biol 2020. doi: 10.1016/j.redox.2020.101530

Sies H, Jones DP: Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Mol Cell Biol 2020. doi: 10.1038/s41580-020-0230-3

Schikowski T, Altug H: The role of air pollution in cognitive impairment and decline. Neurochem Int 21: 104708, 2020. doi: 10.1016/j.neuint.2020.104708

Schikowski T, Hüls A: Air pollution and skin aging. Curr Environ Health Rep 7(1): 58-64, 2020. doi: 10.1007/s40572-020-00262-9

Krutmann J, Passeron T, Gilaberte Y, Granger C, Leone G, Narda M, Schalka S, Trullas C, Masson P, Lim HW: Photoprotection of the future: Challenges and opportunities. J Eur Acad Dermatol Venereol 34(3): 447-454, 2020. doi: 10.1111/jdv.16030

Barenys M, Reverte I, Masjosthusmann S, Gómez-Catalán J, Fritsche E: Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway. Neurotoxicology 78: 209-241, 2020. doi: 10.1016/j.neuro.2019.12.007