AG Schins - Publikationen
2020
Wahle T, Sofranko A, Dekkers S, Miller MR; Heusinkveld HJ, Albrecht C, Cassee FR, Schins RPF: Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer’s and vascular disease. Neurochem Int 2020. doi: 10.1016/j.neuint.2020.104755
Kämpfer AAM, Busch M, Schins RPF: Advanced in vitro testing strategies and models of the intestine for nanosafety research. Chem Res Toxicol 33(5): 1163-1178, 2020. doi: 10.1021/acs.chemrestox.0c00079
Boots AW, Veith C, Albrecht C, Bartholome R, Drittij MJ, Claessen SMH, Bast A, Rosenbruch M, Jonkers L, van Schooten FJ, Schins RPF: The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice. BMC Pulm Med 20: 112, 2020. doi: 10.1186/s12890-020-1142-x
2019
Pavan C,
Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison
D, Lo Giudice C, Martra G, Montfort E, Schins RPF, Sulpizi M, Wegner K,
Wyart-Remy M, Ziemann C, Turci F: The puzzling issue of silica toxicity: are
silanols bridging the gaps between surface states and pathogenicity? Part
Fibre Toxicol 16(1): 32, 2019. doi: 10.1186/s12989-019-0315-3
Soppa VJ,
Shinnawi S, Hennig F, Sasse B, Hellack B, Kaminski H, Quass U, Schins RPF, Kuhlbusch TAJ, Hoffmann B: Effects of
short-term exposure to fine and ultrafine particles from indoor sources on
arterial stiffness – a randomized sham-controlled exposure study. Int J Hyg
Environ Health 222(8): 1115-1132, 2019. doi: 10.1016/j.ijheh.2019.08.002
Cakmak G, Ertürk Ari P, Emerce E, Arı A, Odabası M, Schins RPF, Burgaz S, Gaga EO:
Investigation of spatial and temporal variation of particulate matter
in vitro genotoxicity and cytotoxicity in relation to the elemental
composition. Mutat Res Gen Tox En 842: 22-34, 2019. doi: 10.1016/j.mrgentox.2019.01.009
2018
Dekkers
S, Ma-Hock L, Lynch I, Russ M, Miller MR, Schins RPF, Keller J, Römer I,
Küttler K, Strauss V, De Jong WH, Landsiedel R, Cassee FR: Differences in the toxicity of cerium dioxide
nanomaterials after inhalation can be explained by lung deposition, animal
species and nanoforms. Inhal Toxicol 30(7-8): 273-286, 2018.
doi: 10.1080/08958378.2018.1516834
Perkins TN, Peeters PM, Albrecht C, Schins RPF, Dentener MA, Mossman BT, Wouters EFM, Reynaert NL: Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells. Toxicol Appl Pharmacol 348: 43-53, 2018. doi: 10.1016/j.taap.2018.04.011
Ispanixtlahuatl-Meráz O, Schins RPF, Chirino YI: Cell type specific cytoskeleton disruption induced by engineered nanoparticles. Environ Sci Nano 5: 228-245, 2018. doi: 10.1039/C7EN00704C
Proquin H, Jetten MJ, Jonkhout MCM, Garduño-Balderas LG, Briedé JJ, de Kok TM, Chirino YI, van Loveren H: Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171). Food Chem Toxicol 111: 153-165, 2018. doi: 10.1016/j.fct.2017.11.011
2017
Hellack B, Nickel C, Schins RPF: Oxidative potential of silver nanoparticles measured by electron paramagnetic resonance spectroscopy. J Nanopart Res 19: 404, 2017. doi: 10.1007/s11051-017-4084-3
Benvegnù S, Wahle T, Dotti CG: E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget 8(52): 89439-89450, 2017. doi: 10.18632/oncotarget.20143
Hellack B, Sugiri D, Schins RPF, Schikowski T, Krämer U, Kuhlbusch TAJ, Hoffmann B: Land use regression modeling of oxidative potential of fine particles, NO2, PM2.5 mass and association to type two diabetes mellitus. Atmos Environ 171: 181-190, 2017. doi: 10.1016/j.atmosenv.2017.10.017
Hullmann M, Albrecht C, van Berlo D,
Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins
RPF: Diesel engine exhaust accelerates plaque formation in a mouse model of
Alzheimer’s disease. Part Fibre Toxicol 14: 35,
2017. doi: 10.1186/s12989-017-0213-5
Hellack B, Nickel C, Albrecht C, Kuhlbusch TAJ, Boland S, Baeza-Squiban A, Wohlleben W, Schins RPF: Analytical methods to assess the oxidative potential of nanoparticles: a review. Environ Sci Nano 4: 1920-1934, 2017. doi: 10.1039/c7en00346c
Dekkers S, Miller MR, Schins RPF, Römer I, Russ M, Vandebriel RJ, Lynch I, Belinga-Desaunay MF, Valsami-Jones E, Connell S, Smith IP, Duffin R, Boere JAJF, Heusinkveld HJ, Albrecht C, de Jong WH, Cassee FR: The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation. Nanotoxicology 11(6): 794-808, 2017. doi: 10.1080/17435390.2017.1357214
Sthijns MMJPE*, Thongkam W*, Albrecht C, Hellack B, Bast A, Haenen GRMM, Schins RPF: Silver nanoparticles induce hormesis in A549 human epithelial cells. Toxicol In Vitro 40: 223-233, 2017. doi: 10.1016/j.tiv.2017.01.010 (* equal contribution)
Soppa VJ, Schins RPF, Hennig F, Nieuwenhuijsen MJ, Hellack B, Quass U, Kaminski H, Sasse B, Shinnawi S, Kuhlbusch TAJ, Hoffmann B: Arterial blood pressure responses to short-term exposure to fine and ultrafine particles from indoor sources - A randomized sham-controlled exposure study of healthy volunteers. Environ Res 158: 225-232, 2017. doi: 10.1016/j.envres.2017.06.006
Thongkam W*, Gerloff K*, van Berlo D, Albrecht C, Schins FPR: Oxidant
generation, DNA damage and cytotoxicity by a panel of engineered
nanomaterials in three different human epithelial cell lines. Mutagenesis 32(1): 105-115, 2017. doi: 10.1093/mutage/gew056 (* equal contribution)
Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF,
Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TAJ, Schwarze PE, Hoet P,
Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR: Nanomaterials vs ambient ultrafine particles: an opportunity to exchange toxicology knowledge. Environ Health Perspect 125(10): 106002, 2017. doi: 10.1289/EHP424
2016
Heusinkveld HJ, Wahle T, Campbell A, Westerink RHS, Tran L, Johnston H, Stone V, Cassee FR, Schins RPF: Neurodegenerative and neurological disorders by small inhaled particles. Neurotoxicology 56: 94-106, 2016. doi: 10.1016/j.neuro.2016.07.007
Nehr S, Gladtke D, Hellack B, Hermann H, Hoffmann B, Kuhlbusch TAJ, Schins RPF, Wiesen P, Zellner R: Tropospheric aerosols – Current research and future air quality policy. Gefahrst Reinh Luft 76(6): 231-237, 2016. (abstract)
Heusinkveld HJ, van Vliet AC, Nijssend PCG, Westerink RHS: In vitro neurotoxic hazard characterisation of dinitrophenolic herbicides. Toxicol Lett 252: 62-69, 2016. doi: 10.1016/j.toxlet.2016.04.014
Kermanizadeh A, Gosens G, Johnston H, Danielsen PH, Jacobsen NR, Lenz AG, Fernandes T, Schins RPF, Cassee FR, Wallin H, Kreyling W, Stoeger T, Loft S, Møller P, Tran L, Stone V: A multi-laboratory toxicological assessment of a panel of ten engineered nanomaterials to human health - ENPRA project - the highlights, the limitations and the current and future challenges. J Toxicol Environ Health B Crit Rev 19(1): 1-28, 2016. doi: 10.1080/10937404.2015.1126210
Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA: PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models. Nat Neurosci 19(3): 443-453, 2016. doi: 10.1038/nn.4225
2015
Peeters PM, Wouters EF, Reynaert NL: Immune homeostasis in epithelial cells: evidence and role of inflammasome signaling reviewed. J Immunol Res 2015: 828264. [pubmed] (open access)
Hellack
B, Quass U, Beuck H, Wick G, Kuttler W, Schins RPF, Kuhlbusch TAJ: Elemental
composition and radical formation potency of PM10 at an urban background station
in Germany in relation to origin of air masses. Atmos Environ 105:
1-6, 2015. (abstract)
Hellack B, Quass U, Nickel C, Wick G, Schins RPF, Kuhlbusch TAJ: Oxidative potential of particulate matter at a German motorway. Environ Sci Process Impacts 17(4): 868-876, 2015. [pubmed]
Klümper
C, Krämer U, Lehmann I, von Berg A, Berdel D, Herberth G, Beckmann C,
Link E, Heinrich J, Hoffmann B, Schins RPF (for the GINIplus and
LISAplus study groups): Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children. Environ Res 138: 381-390, 2015. [pubmed]
2014
Meijer M, Hendriks HS, Heusinkveld HJ, Langeveld WT, Westerink RH: Comparison of plate reader-based methods with fluorescence microscopy for measurements of intracellular calcium levels for the assessment of in vitro neurotoxicity. Neurotoxicology 45: 31-37, 2014. [pubmed]
Peeters PM, Eurlings IMJ, Perkins TN, Wouters EF, Schins RPF, Borm PJA, Drommer W, Reynaert NL, Albrecht C: Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs. Particle and Fibre Toxicology 11(1): 58, 2014. [pubmed] (open access)
van Berlo D*, Wilhelmi V*, Boots AW, Hullmann M, Kuhlbusch TAJ, Bast A, Schins RPF, Albrecht C: Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung. Arch Toxicol 88(9): 1725-1737, 2014. (*equal contribution) [pubmed]
Clift MJD, Endes C, Vanhecke D, Wick P, Gehr P, Schins RPF, Petri-Fink A, Rothen-Rutishauser B: A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes. Toxicological Sciences 137(1): 55-64, 2014. [pubmed]
Autengruber A, Sydlik U, Kroker M, Hornstein T, Ale-Agha N, Stöckmann D, Bilstein A, Albrecht C, Paunel-Görgülü A, Suschek CV, Krutmann J, Unfried K: Signalling-dependent adverse health effects of carbon nanoparticles are prevented by the compatible solute beta mannosylglycerate (firoin) in vitro and in vivo. Plos one 9(11): e111485, 2014. [pubmed]
Hellack B, Yang A, Cassee FR, Janssen NAH, Schins RPF, Kuhlbusch TAJ: Intrinsic hydroxyl radical generation measurements directly from sampled filters as a metric for the oxidative potential of ambient particulate matter. J Aerosol Sci 72, 47-55, 2014.
Van Berlo D*, Hullmann M*, Wessels A, Scherbart AM, Cassee FR, Gerlofs-Nijland ME, Albrecht C, Schins RPF. Investigation of the effects of short-term inhalation of carbon nanoparticles on brains and lungs of C57BL/6J and p47phox-/- mice. Neurotoxicology 43: 65-72, 2014. (* equal contribution) [pubmed]
Soppa VJ, Schins RPF, Hennig F, Hellack B, Quass U, Kaminski H, Kuhlbusch TAJ, Hoffmann B, Weinmayr G: Respiratory effects of fine and ultrafine particles from indoor sources- a randomized sham-controlled exposure study of healthy volunteers. Int J Environ Res Public Health 11(7): 6871-6889, 2014. [pubmed] (open access)
Birmili W, Rückerl R, Hoffmann B, Weinmayr G, Schins R, Kuhlbusch TAJ, Vogel A, Weber K, Franck U, Cyrys J, Peters A: Ultrafine aerosol particles in ambient air: Perspectives to elucidate their health effects (Ultrafeine Aerosolpartikel in der Außenluft: Perspektiven zur Aufklärung ihrer Gesundheitseffekte). Gefahrst Reinh Luft 74(11/12): 492-500, 2014.
Boland S, Vranic S, Schins RPF, Stöger T: Current in vitro models for nanomaterial testing in pulmonary systems. In: Nanotoxicology (2nd Edition): Progress Towards Nanomedicine (Monteiro-Riviere N, Tran CL, Eds). CRC Press 2014, pp. 291-314.
2013
Gerloff K, Pereira DIA, Faria N, Boots AW, Kolling J, Förster I, Albrecht C, Powell JJ, Schins RPF. Influence of simulated gastro-intestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells. Nanotoxicology 7: 353-366, 2013. [pubmed]
Clift MJD, Raemy DO, Zulqurnain A, Endes C, Lehmann AD, Brandenberger C, Peter-Fink A, Wick P, Parak WJ, Gehr P, Schins RPF, Rothen-Rutushauser B: Can the Ames test provide an insight into nano-object mutagenicity?; Investigating the interaction between nano-objects and bacteria. Nanotoxicology 7: 1373-1385, 2013. [pubmed]
Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RPF, Albrecht C. Zinc Oxide Nanoparticles Induce Necrosis and Apoptosis in Macrophages in a p47phox- and Nrf2-Independent Manner. PLoS One 8(6): e65704, 2013. [pubmed]
Schins RPF: Genotoxicity of Nanoparticles. In: Deutsche Forschungsgemeinschaft (DFG) (ed). Nanomaterials. Wiley-VCH, Weinheim, Germany, 1st Edition, 2013, pp. 60-64.
2012
Boots AW, Gerloff K, Bartholome R, Van Berlo D, Ledermann K, Haenen GR, Bast A, Van Schooten FJ, Albrecht C, Schins RPF: Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells. Biochimica et Biophysica Acta – Molecular Cell Research 1823 (7):1151-1162, 2012. [pubmed]
Bhattacharya K, Hoffmann E, Schins RPF, Boertz J, Prantl EM, Alink GM, Byrne HJ, Kuhlbusch TAJ,Rahman Q, Wiggers H, Schulz C, Dopp E: Comparison of micro- and nanoscale Fe+3-containing (hematite) particles for their toxicological properties in human lung cells in vitro. Toxicol Sci 126(1): 173-182, 2012. [pubmed]
Gerloff K, Fenoglio I Carella E, Kolling J, Albrecht C, Boots A, Förster I, Schins R: Distinctive toxicity of TiO2 rutile/anatase mixed phases nanoparticles on Caco-2 cells. Chemical Research in Toxicology 25(3): 646-655, 2012. [pubmed]
Wilhelmi V, Fischer U, van Berlo D, Schulze-Osthoff K, Schins RPF, Albrecht C: Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts. Toxicology in vitro 26(2): 323-334, 2012. [pubmed]
Schins RPF, Albrecht C, Gerloff K, Van Berlo D: Genotoxicity of carbon nanotubes. In: (Donaldson K, Poland C, Duffin R, Eds.) The Inhalation Toxicology of Carbon Nanotubes. Cambridge University Press, UK, 2012, pp.150-173.
Van Berlo D, Clift M, Albrecht C, Schins RPF. Carbon nanotubes: An insight into the mechanisms of their potential genotoxicity. Swiss Medical Weekly 142:w13698, 2012.
van Berlo D, Hullmann M, Schins RPF: Toxicology of ambient particulate matter. In: (Luch A, Ed.) Molecular, Clinical and Environmental Toxicology. Volume 3. Molecular Toxicology Series: Experientia Supplementum, Birkhäuser Basel, pp. 165-217.
2011
Scherbart AM, Langer J, Bushmelev A, van Berlo D,
Haberzettl P, van Schooten FJ, Schmidt AM, Rose CR, Schins RPF, Albrecht C: Contrasting macrophage activation by fine and ultrafine titanium
dioxide particles is associated with different uptake mechanisms. Part Fibre Toxicol 8(1): 31, 2011. [pubmed]
Ghiazza M, Scherbart AM, Fenoglio I, Grendene F,
Turci F, Martra G, Albrecht C, Schins RP, Fubini B: Surface iron
inhibits quartz-induced cytotoxic and inflammatory responses in
alveolar macrophages. Chem Res Toxicol
24(1): 99-110, 2011. [pubmed]
Wessels A, van Berlo D, Boots AW, Gerloff K,
Scherbart AM, Cassee F, Gerlofs-Nijland M, Van Schooten F,
Albrecht C, Schins RPF: Oxidative stress and DNA damage
responses in rat and mouse lung to inhaled carbon nanoparticles. Nanotoxicology 5: 66-78, 2011. [pubmed]
Winter
M, Beer HD, Hornung V, Krämer U, Schins RPF, Förster I: Activation
of the inflammasome by amorphous silica and TiO2 nanoparticles
in murine dendritic cells. Nanotoxicology 5: 326-40, 2011.
Gerloff K, Albrecht C, Boots AW, Förster I, Schins
RPF. Particles which may occur in food or food packaging can exert cytotoxicity
and (oxidative) DNA damage in target cells of the human intestine. Letter to
the editor. Nanotoxicology 5: 282-283, 2011.
Loft S, Schins RPF, Møller P: Particulates and oxidative stress. In: Cardiovascular Effects of Inhaled Ultrafine and Nano-Sized Particles. Cassee FR, Mills NL, Newby DE (Eds). John Wiley and Sons, New Jersey, USA , pp. 251-271, 2011.
2010
Weissenberg A*, Sydlik
U*, Peuschel H, Schroeder P,
Schneider M, Schins RP, Abel J, Unfried K: Reactive oxygen
species as mediators of membrane-dependent signaling induced by
ultrafine particles. Free Radic Biol Med 49: 597–605,
2010. (*equal contribution)
van Berlo D, Wessels A, Boots A, Wilhelmi V,
Scherbart A, Gerloff K, van Schooten FJ, Albrecht C, Schins R: Neutrophil-derived ROS contribute to oxidative DNA damage
induction by quartz particles. Free Radic Biol Med
49(11):1685-93, 2010.
Wessels A, Birmili W, Albrecht C, Hellack B, Jermann
E, Wick G, Harrison RM, Schins RPF: Oxidant generation and
toxicity of size-fractionated ambient particles in A549 human
lung epithelial cells. Environ Sci Technol 44 (9): 3539-3545,
2010.
Demircigil Cakmak G, Coskun E,
Vidinli N, Erbas Y, Yilmaz M, Cimrin A, Schins RPF, Borm PJA,
Burgaz S: Increased micronucleus frequencies in surrogate and
target cells from workers exposed to crystalline silica
containing dust.
Mutagenesis 25: 163-169, 2010.
van Berlo D,
Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME,
Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ,
Krutmann J, Schins RPF: Comparative evaluation of the effects of short-term
inhalation exposure to diesel engine exhaust on rat lung and
brain. Arch Toxicol 84 (7): 553-562,
2010.
Orru H, Kimmel V, Kikas Ü,
Soon A, Künzli N, Schins RPF, Borm PJA, Forsberg B: Elemental
Composition and Oxidative Properties of PM2.5 in Estonia in
Relation of Origin of Air Masses - results from ERCHS II in
Tartu. Sci
Tot Environ 408 (7): 1515-1522, 2010.
Gerlofs-Nijland M,
van Berlo D, Cassee FR, Schins RPF, Wang K, Campbell A: Effects of prolonged exposure to diesel engine exhaust on
proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol 7 (1): 12, 2010.
van Berlo D, Knaapen AM, van Schooten FJ, Schins RP,
Albrecht C: NF-kappaB dependent and independent mechanisms of
quartz-induced proinflammatory activation of lung epithelial
cells. Part Fibre Toxicol 7 (1): 13, 2010.
Donaldson K, Poland C, Schins RPF: Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies. Nanotoxicology 4: 414-420, 2010.
2009
Gerlofs-Nijland ME,
Rummelhard M, Boere JF, Leseman DLAC, Duffin R, Schins RPF, Borm
PJA, Sillanpää M, Salonen RO, Cassee FR: Particle induced
toxicity in relation to Transition Metal and Polycyclic Aromatic
Hydrocarbon contents. Environ Sci Technol 43 (13): 4729-4736, 2009.
Gerloff K, Albrecht C, Boots
AW, Förster I, Schins RPF: Cytotoxicity and oxidative DNA damage by nanoparticles in
human intestinal Caco-2 cells. Nanotoxicology 3 (4): 355-364, 2009.
Van Berlo D, Haberzettl P, Gerloff K, Li H,
Scherbart AM, Albrecht C, Schins RPF: Investigation of the
cytotoxic and proinflammatory effects of cement dusts in rat
alveolar macropages. Chemical
Research in Toxicology 22 (9): 1548-1558, 2009.
Baulig A, Singh S, Marchand A, Schins R, Barouki R,
Garlatti M, Marano F, Baeza-Squiban A: Role of Paris PM(2.5)
components in the pro-inflammatory response induced in airway
epithelial cells. Toxicology 261 (3): 126-135, 2009.
Herberth G, Gubelt R, Röder S, Krämer U, Schins
RP, Diez U, Borte M, Heinrich J, Wichmann HE, Herbarth O, Lehmann I: Increase of inflammatory markers after indoor renovation activities:
The LISA birth cohort study. Pediatr Allergy Immunol 20 (6): 563-570, 2009.
Albrecht
C, Scherbart AM, Berlo D, Braunbarth CM, Schins RPF, Scheel J: Evaluation
of cytotoxic effects and oxidative stress with hydroxyapatite
dispersions of different physicochemical properties in rat NR8383
cells and primary macrophages. Toxicology
in Vitro 23 (3): 520-530, 2009.
Jalava PI, Hirvonen
MR, Sillanpää M, Pennanen AS,
Happo MS, Hillamo R, Cassee FR, Gerlofs-Nijland M, Borm PJ,
Schins RP, Janssen NA, Salonen RO: Associations
of urban air particulate composition with inflammatory and
cytotoxic responses in RAW 246.7 cell line. Inhalation Toxicology 21 (12):
994-1006, 2009.
Bhattacharya K, Davoren M, Boertz J, Schins RP,
Hoffmann E, Dopp E: Titanium dioxide nanoparticles induce oxidative
stress and DNA adduct formation but not DNA breakage in human lung
cells. Part Fibre Toxicol 6 (1): 17, 2009.
Stone V, Johnston H, Schins RPF: Development of in vitro systems for Nanotoxicology – Methodological Considerations. Crit Rev Toxicol 39 (7), 613-626, 2009.
2008
Mroz RM, Schins RPF,
Li H, Jimenez LA, Drost EM, Holownia A, MacNee W, Donaldson K: Nanoparticle-driven DNA damage mimics irradiation-related
carcinogenesis pathways. Eur Respir J 31: 241-251, 2008.
Haberzettl P,
Schins RPF, Höhr D, Wilhelmi V, Borm PJA, AlbrechtC: Impact of the
FcgammaII-receptor on quartz uptake and inflammatory response by
alveolar macrophages. Am J
Physiol – Lung Cell Mol Biol 294 (6):
L1137-1148, 2008.
Papageorgiou I, Shadrick V, Davis S, Hails L, Schins RPF, Newson R, Fisher J, Ingham E, Case
CP: Macrophages detoxify the
genotoxic and cytotoxic effectsd of surgical cobal chrome alloy
particles but not quartz particles on human cells in vitro. Mutation
Research - Fundamental and Molecular Mechanisms of Mutagenesis 643
(1-2): 11-19, 2008.
Li H, van Berlo D, Shi T, Speit G, Knaapen AM, Borm
PJA, Albrecht C, Schins RPF: Curcumin protects against cytotoxic and
inflammatory effects of quartz particles but causes oxidative DNA
damage in a rat lung epithelial cell line. Tox Appl Pharmacol 227:115-124, 2008.
Bhattacharya K, Cramer H, Albrecht C, Schins R, Rahman Q, Zimmermann U, Dopp E: Vanadium pentoxide coated ultrafine titanium dioxide particles induce cellular damage and micronucleus formation in V79-cells. J Toxicol Environ Health A 71: 976-980, 2008.
2007
Papageorgiou I,
Brown C, Schins R, Singh S, Newson R, Davis S, Fisher J, Ingham
E, Case CP: The effect of nano- and micron-sized particles of cobalt
chromium alloy on human fibroblasts in vitro. Biomaterials28 (19): 2946-2958, 2007.
Boots AW, Li H, Schins
RP, Duffin R, Heemskerk JWM , Bast A, Haenen GR: The quercetin paradox. Toxicology
and Applied Pharmacology 222: 89-96, 2007.
Singh S, Shi T, Duffin R, Albrecht C, van Berlo D, Höhr
D, Fubini B, Martra G, Fenoglio I, Borm PJA, Schins RPF: Endocytosis,
oxidative stress and IL-8 expression in human lung epithelial cells
upon treatment with fine and ultrafine TiO2: role of the specific
surface area and of surface methylation of the particles. Toxicology
and Applied Pharmacology 222: 141-151, 2007.
Godschalk RW,
Albrecht C, Curfs DMJ, Schins RPF, Bartsch H, van Schooten FJ,
Nair J: Decreased levels of lipid peroxidation induced DNA damage in
early atherogenesis in apolipoprotein E- knockout mice. Mutation Research – Fundamental and Molecular Mechanisms
of Mutagenesis 621(1-2): 87-94, 2007.
Li H, Haberzettl P, Albrecht C, Höhr D, Knaapen AM,
Borm PJA, Schins RPF: Inhibition of the mitochondrial respiratory
chain function abrogates quartz induced DNA damage in lung epithelial
cells. Mutation
Research – Fundamental and Molecular Mechanisms of Mutagenesis 617
(1-2), 46-57, 2007.
Mroz RM, Schins RPF, Li
H, Drost EM, MacNee W, Donaldson K: Nanoparticle carbon black driven DNA damage induces growth arrest
and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line. J Physiol Pharmacol 58 (suppl. 5), 461-470, 2007.
Albrecht C, Höhr D,
Haberzettl, Becker A, Borm PJA, Schins RPF: Surface-dependent quartz-uptake by macrophages: potential role in
pulmomonary inflammation and lung clearance. Inhalation Toxicology 19 (1): 39-48, 2007.
Haberzettl P, Duffin R, Krämer U, Höhr D, Schins
R, Borm PJA, Albrecht C: Actin plays a crucial role in the
phagocytosis and biological responses to respirable quartz particles
in macrophages. Archives of Toxicology 81 (7): 459-470, 2007.
Borm PJA, Kelly F, Künzli N, Schins
RPF, Donaldson
K: Oxidant generation by particulate matter: from biologically
effective dose to a promising, novel metric. Occup
Environ Med 64(2): 73-74, 2007.
Unfried K, Albrecht C,
Klotz LO, von Mikecz A, Grether-Beck S, Schins RPF: Cellular responses to nanoparticles: target structures and
mechanisms. Nanotoxicology 1: 52-71, 2007.
Schins RPF, Knaapen AM: Genotoxicity of poorly soluble particles. Inhal Toxicol 19(1) 189-198, 2007.
2006
Sydlik U, Bierhals
K, Soufi M, Abel J, Schins R, Unfried K: Ultrafine carbon particles induce apoptosis and proliferation
in rat lung epithelial cells via specific signaling pathways
both using EGF-R. Am J Physiol Lung Cell Mol Physiol 291 (4): L725-L733,
2006.
Herberth G,
Daegelmann C, Weber A, Roder S, Giese T, Kramer U, Schins RP,
Behrendt H, Borte M, Lehmann I; for the LISAplus study group: Association of neuropeptides with Th1/Th2 balance and
allergic sensitization in children. Clin Exp Allergy 36 (11): 1408-1416, 2006.
Øvrevik J, Hetland
RB, Schins PRF, Myran T, Schwarze PE: Iron release and ROS-generation from mineral particles are
not related to cytokine release or apoptosis in exposed A549
cells. Toxicol Letters 165 (1) 31-38, 2006.
Shi T, Duffin R,
Borm PJA, Li H, Weishaupt C, Schins RPF: Involvement of hydroxyl radical generation in particulate
matter induced DNA damage. Environ Res 101 (1): 18-24, 2006.
Geh S, Shi T,
Shokouhi B, Schins RPF, Armbruster L, Rettenmeier AW, Dopp E: Genotoxic potential of respirable bentonite particles with
different quartz contents and chemical modifications in human
lung fibroblasts. Inhalation Toxicology 18 (6): 405-412, 2006.
Becker A, Albrecht
C, Schins RPF, Höhr D, Ledermann K, Knaapen AM, Borm PJA: Induction of CYP1A1 in rat lung cells following in vivo and
in vitro exposure to quartz. Archives of Toxicology 80 (5): 258-268, 2006.
Borm PJA, Schins
RPF: Toxicological characterization of engineered nanoparticles. In: Nanoparticle Technology for Drug Delivery. Eds.
RB Gupta, UB Kompella. New York: Marcel Dekker 2006, pp.
161-197.
Borm PJA ,
Robbins R, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins
RPF, Stone V, Kreyling W, Lademann J, Krutmann J, Warheit
D, Oberdorster E: The potential risks of nanomaterials: a review carried out for
ECETOC. Particle and Fibre Toxicology 3:11, 2006.
Knaapen
AM, Güngör N, Schins RPF, Borm PJA, van Schooten FJ: Neutrophils
and respiratory tract DNA damage and mutagenesis: a review. Mutagenesis
21, 225-236, 2006.
Schins RPF, Hei TK: Genotoxic Effects of Particles. In: Particle toxicology (Eds: Donaldson K, Borm P). Boca Raton, CRC Press/Taylor & Francis Group 2006, pp. 285-298.