AG Schins - Publikationen


Wahle T, Sofranko A, Dekkers S, Miller MR; Heusinkveld HJ, Albrecht C, Cassee FR, Schins RPF: Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer’s and vascular disease. Neurochem Int 2020. doi: 10.1016/j.neuint.2020.104755

Kämpfer AAM, Busch M, Schins RPF: Advanced in vitro testing strategies and models of the intestine for nanosafety research. Chem Res Toxicol 33(5): 1163-1178, 2020. doi: 10.1021/acs.chemrestox.0c00079

Boots AW,  Veith C, Albrecht C, Bartholome R, Drittij MJ, Claessen SMH, Bast A, Rosenbruch M, Jonkers L, van Schooten FJ, Schins RPF: The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice. BMC Pulm Med 20: 112, 2020. doi: 10.1186/s12890-020-1142-x


Pavan C, Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison D, Lo Giudice C, Martra G, Montfort E, Schins RPF, Sulpizi M, Wegner K, Wyart-Remy M, Ziemann C, Turci F: The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity? Part Fibre Toxicol 16(1): 32, 2019. doi: 10.1186/s12989-019-0315-3

Soppa VJ, Shinnawi S, Hennig F, Sasse B, Hellack B, Kaminski H, Quass U, Schins RPF, Kuhlbusch TAJ, Hoffmann B: Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness – a randomized sham-controlled exposure study. Int J Hyg Environ Health 222(8): 1115-1132, 2019. doi: 10.1016/j.ijheh.2019.08.002

Cakmak G, Ertürk Ari P, Emerce E, Arı A, Odabası M, Schins RPF, Burgaz S, Gaga EO: Investigation of spatial and temporal variation of particulate matter in vitro genotoxicity and cytotoxicity in relation to the elemental composition. Mutat Res Gen Tox En 842: 22-34, 2019. doi: 10.1016/j.mrgentox.2019.01.009


Dekkers S, Ma-Hock L, Lynch I, Russ M, Miller MR, Schins RPF, Keller J, Römer I, Küttler K, Strauss V, De Jong WH, Landsiedel R, Cassee FR: Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms. Inhal Toxicol 30(7-8): 273-286, 2018. doi: 10.1080/08958378.2018.1516834

Perkins TN, Peeters PM, Albrecht C, Schins RPF, Dentener MA, Mossman BT, Wouters EFM, Reynaert NL: Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells. Toxicol Appl Pharmacol 348: 43-53, 2018. doi: 10.1016/j.taap.2018.04.011

Ispanixtlahuatl-Meráz O, Schins RPF, Chirino YI: Cell type specific cytoskeleton disruption induced by engineered nanoparticles. Environ Sci Nano 5: 228-245, 2018. doi: 10.1039/C7EN00704C

Proquin H, Jetten MJ, Jonkhout MCM, Garduño-Balderas LG, Briedé JJ, de Kok TM, Chirino YI, van Loveren H: Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171). Food Chem Toxicol 111: 153-165, 2018. doi: 10.1016/j.fct.2017.11.011


Hellack B, Nickel C, Schins RPF: Oxidative potential of silver nanoparticles measured by electron paramagnetic resonance spectroscopy. J Nanopart Res 19: 404, 2017. doi: 10.1007/s11051-017-4084-3

Benvegnù S, Wahle T, Dotti CG: E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget 8(52): 89439-89450, 2017. doi: 10.18632/oncotarget.20143

Hellack B, Sugiri D, Schins RPF, Schikowski T, Krämer U, Kuhlbusch TAJ, Hoffmann B: Land use regression modeling of oxidative potential of fine particles, NO2, PM2.5 mass and association to type two diabetes mellitus. Atmos Environ 171: 181-190, 2017. doi: 10.1016/j.atmosenv.2017.10.017

Hullmann M, Albrecht C, van Berlo D, Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins RPF: Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease. Part Fibre Toxicol 14: 35, 2017. doi: 10.1186/s12989-017-0213-5

Hellack B, Nickel C, Albrecht C, Kuhlbusch TAJ, Boland S, Baeza-Squiban A, Wohlleben W, Schins RPF: Analytical methods to assess the oxidative potential of nanoparticles: a review. Environ Sci Nano 4: 1920-1934, 2017. doi: 10.1039/c7en00346c

Dekkers S, Miller MR, Schins RPF, Römer I, Russ M, Vandebriel RJ, Lynch I, Belinga-Desaunay MF, Valsami-Jones E, Connell S, Smith IP, Duffin R, Boere JAJF, Heusinkveld HJ, Albrecht C, de Jong WH, Cassee FR: The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation. Nanotoxicology 11(6): 794-808, 2017. doi: 10.1080/17435390.2017.1357214

Sthijns MMJPE*, Thongkam W*, Albrecht C, Hellack B, Bast A, Haenen GRMM, Schins RPF: Silver nanoparticles induce hormesis in A549 human epithelial cells. Toxicol In Vitro 40: 223-233, 2017. doi: 10.1016/j.tiv.2017.01.010 (* equal contribution)

Soppa VJ, Schins RPF, Hennig F, Nieuwenhuijsen MJ, Hellack B, Quass U, Kaminski H, Sasse B, Shinnawi S, Kuhlbusch TAJ, Hoffmann B: Arterial blood pressure responses to short-term exposure to fine and ultrafine particles from indoor sources - A randomized sham-controlled exposure study of healthy volunteers. Environ Res 158: 225-232, 2017. doi: 10.1016/j.envres.2017.06.006

Thongkam W*, Gerloff K*, van Berlo D, Albrecht C, Schins FPR: Oxidant generation, DNA damage and cytotoxicity by a panel of engineered nanomaterials in three different human epithelial cell lines. Mutagenesis 32(1): 105-115, 2017. doi: 10.1093/mutage/gew056 (* equal contribution)

Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR: Nanomaterials vs ambient ultrafine particles: an opportunity to exchange toxicology knowledge. Environ Health Perspect 125(10): 106002, 2017. doi: 10.1289/EHP424


Heusinkveld HJ, Wahle T, Campbell A, Westerink RHS, Tran L, Johnston H, Stone V, Cassee FR, Schins RPF:  Neurodegenerative and neurological disorders by small inhaled particles. Neurotoxicology 56: 94-106, 2016. doi: 10.1016/j.neuro.2016.07.007

Nehr S, Gladtke D, Hellack B, Hermann H, Hoffmann B, Kuhlbusch TAJ, Schins RPF, Wiesen P, Zellner R: Tropospheric aerosols – Current research and future air quality policy. Gefahrst Reinh Luft 76(6): 231-237, 2016. (abstract)

Heusinkveld HJ, van Vliet AC, Nijssend PCG, Westerink RHS: In vitro neurotoxic hazard characterisation of dinitrophenolic herbicides. Toxicol Lett 252: 62-69, 2016. doi: 10.1016/j.toxlet.2016.04.014

Kermanizadeh A, Gosens G, Johnston H, Danielsen PH, Jacobsen NR, Lenz AG, Fernandes T, Schins RPF, Cassee FR, Wallin H, Kreyling W, Stoeger T, Loft S, Møller P, Tran L, Stone V: A multi-laboratory toxicological assessment of a panel of ten engineered nanomaterials to human health - ENPRA project - the highlights, the limitations and the current and future challenges. J Toxicol Environ Health B Crit Rev 19(1): 1-28, 2016. doi: 10.1080/10937404.2015.1126210

Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA: PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models. Nat Neurosci 19(3): 443-453, 2016. doi: 10.1038/nn.4225


Peeters PM, Wouters EF, Reynaert NL: Immune homeostasis in epithelial cells: evidence and role of inflammasome signaling reviewed. J Immunol Res 2015: 828264. [pubmed] (open access)

Hellack B, Quass U, Beuck H, Wick G, Kuttler W, Schins RPF, Kuhlbusch TAJ: Elemental composition and radical formation potency of PM10 at an urban background station in Germany in relation to origin of air masses. Atmos Environ 105: 1-6, 2015. (abstract)

Hellack B, Quass U, Nickel C, Wick G, Schins RPF, Kuhlbusch TAJ: Oxidative potential of particulate matter at a German motorway. Environ Sci Process Impacts 17(4): 868-876, 2015. [pubmed]

Klümper C, Krämer U, Lehmann I, von Berg A, Berdel D, Herberth G, Beckmann C, Link E, Heinrich J, Hoffmann B, Schins RPF (for the GINIplus and LISAplus study groups): Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children. Environ Res 138: 381-390, 2015. [pubmed]


Meijer M, Hendriks HS, Heusinkveld HJ, Langeveld WT, Westerink RH: Comparison of plate reader-based methods with fluorescence microscopy for measurements of intracellular calcium levels for the assessment of in vitro neurotoxicity. Neurotoxicology 45: 31-37, 2014. [pubmed]

Peeters PM, Eurlings IMJ, Perkins TN, Wouters EF, Schins RPF, Borm PJA, Drommer W, Reynaert NL, Albrecht C: Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs. Particle and Fibre Toxicology 11(1): 58, 2014. [pubmed] (open access)

van Berlo D*, Wilhelmi V*, Boots AW, Hullmann M, Kuhlbusch TAJ, Bast A, Schins RPF, Albrecht C: Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung. Arch Toxicol 88(9): 1725-1737, 2014. (*equal contribution) [pubmed]

Clift MJD, Endes C, Vanhecke D, Wick P, Gehr P, Schins RPF, Petri-Fink A, Rothen-Rutishauser B: A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes. Toxicological Sciences 137(1): 55-64, 2014. [pubmed]

Autengruber A, Sydlik U, Kroker M, Hornstein T, Ale-Agha N, Stöckmann D, Bilstein A, Albrecht C, Paunel-Görgülü A, Suschek CV, Krutmann J, Unfried K: Signalling-dependent adverse health effects of carbon nanoparticles are prevented by the compatible solute beta mannosylglycerate (firoin) in vitro and in vivo. Plos one 9(11): e111485, 2014. [pubmed]

Hellack B, Yang A, Cassee FR, Janssen NAH, Schins RPF, Kuhlbusch TAJ:  Intrinsic hydroxyl radical generation measurements directly from sampled filters as a metric for the oxidative potential of ambient particulate matter. J Aerosol Sci 72, 47-55, 2014.

Van Berlo D*, Hullmann M*, Wessels A, Scherbart AM, Cassee FR, Gerlofs-Nijland ME, Albrecht C, Schins RPF. Investigation of the effects of short-term inhalation of carbon nanoparticles on brains and lungs of C57BL/6J and p47phox-/- mice. Neurotoxicology 43: 65-72, 2014. (* equal contribution) [pubmed]

Soppa VJ, Schins RPF, Hennig F, Hellack B, Quass U, Kaminski H, Kuhlbusch TAJ, Hoffmann B, Weinmayr G: Respiratory effects of fine and ultrafine particles from indoor sources- a randomized sham-controlled exposure study of healthy volunteers. Int J Environ Res Public Health 11(7): 6871-6889, 2014. [pubmed] (open access)

Birmili W, Rückerl R, Hoffmann B, Weinmayr G, Schins R, Kuhlbusch TAJ, Vogel A, Weber K, Franck U, Cyrys J, Peters A: Ultrafine aerosol particles in ambient air: Perspectives to elucidate their health effects (Ultrafeine Aerosolpartikel in der Außenluft: Perspektiven zur Aufklärung ihrer Gesundheitseffekte). Gefahrst Reinh Luft 74(11/12): 492-500, 2014.

Boland S, Vranic S, Schins RPF, Stöger T: Current in vitro models for nanomaterial testing in pulmonary systems. In: Nanotoxicology (2nd Edition): Progress Towards Nanomedicine (Monteiro-Riviere N, Tran CL, Eds). CRC Press 2014, pp. 291-314.


Gerloff K, Pereira DIA, Faria N, Boots AW, Kolling J, Förster I, Albrecht C, Powell JJ, Schins RPF. Influence of simulated gastro-intestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells. Nanotoxicology 7: 353-366, 2013. [pubmed]

Clift MJD, Raemy DO, Zulqurnain A, Endes C, Lehmann AD, Brandenberger C, Peter-Fink A, Wick P, Parak WJ, Gehr P, Schins RPF, Rothen-Rutushauser B: Can the Ames test provide an insight into nano-object mutagenicity?; Investigating the interaction between nano-objects and bacteria. Nanotoxicology 7: 1373-1385, 2013. [pubmed]

Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RPF, Albrecht C. Zinc Oxide Nanoparticles Induce Necrosis and Apoptosis in Macrophages in a p47phox- and Nrf2-Independent Manner. PLoS One 8(6): e65704, 2013. [pubmed]

Schins RPF: Genotoxicity of Nanoparticles. In: Deutsche Forschungsgemeinschaft (DFG) (ed). Nanomaterials. Wiley-VCH, Weinheim, Germany, 1st Edition, 2013, pp. 60-64.


Boots AW, Gerloff K, Bartholome R, Van Berlo D, Ledermann K, Haenen GR, Bast A, Van Schooten FJ, Albrecht C, Schins RPF: Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells. Biochimica et Biophysica Acta – Molecular Cell Research 1823 (7):1151-1162, 2012. [pubmed]

Bhattacharya K, Hoffmann E, Schins RPF, Boertz J, Prantl EM, Alink GM, Byrne HJ, Kuhlbusch TAJ,Rahman Q, Wiggers H, Schulz C, Dopp E: Comparison of micro- and nanoscale Fe+3-containing (hematite) particles for their toxicological properties in human lung cells in vitro. Toxicol Sci 126(1): 173-182, 2012. [pubmed]

Gerloff K, Fenoglio I Carella E, Kolling J, Albrecht C, Boots A, Förster I, Schins R: Distinctive toxicity of TiO2 rutile/anatase mixed phases nanoparticles on Caco-2 cells. Chemical Research in Toxicology 25(3): 646-655, 2012. [pubmed]

Wilhelmi V, Fischer U, van Berlo D, Schulze-Osthoff K, Schins RPF, Albrecht C: Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts. Toxicology in vitro 26(2): 323-334, 2012. [pubmed]

Schins RPF, Albrecht C, Gerloff K, Van Berlo D: Genotoxicity of carbon nanotubes. In: (Donaldson K, Poland C, Duffin R, Eds.) The Inhalation Toxicology of Carbon Nanotubes. Cambridge University Press, UK, 2012, pp.150-173.

Van Berlo D, Clift M, Albrecht C, Schins RPF. Carbon nanotubes: An insight  into the mechanisms of their potential genotoxicity. Swiss Medical Weekly 142:w13698, 2012.

van Berlo D, Hullmann M, Schins RPF: Toxicology of ambient particulate matter. In: (Luch A, Ed.) Molecular, Clinical and Environmental Toxicology. Volume 3. Molecular Toxicology Series: Experientia Supplementum, Birkhäuser Basel, pp. 165-217.


Scherbart AM, Langer J, Bushmelev A, van Berlo D, Haberzettl P, van Schooten FJ, Schmidt AM, Rose CR, Schins RPF, Albrecht C: Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms. Part Fibre Toxicol 8(1): 31, 2011. [pubmed]

Ghiazza M, Scherbart AM, Fenoglio I, Grendene F, Turci F, Martra G, Albrecht C, Schins RP, Fubini B: Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. Chem Res Toxicol 24(1): 99-110, 2011. [pubmed]

Wessels A, van Berlo D, Boots AW, Gerloff K, Scherbart AM, Cassee F, Gerlofs-Nijland M, Van Schooten F, Albrecht C, Schins RPF: Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles. Nanotoxicology 5: 66-78, 2011. [pubmed]

Winter M, Beer HD, Hornung V, Krämer U, Schins RPF, Förster I: Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells.   Nanotoxicology 5: 326-40, 2011.

Gerloff K, Albrecht C, Boots AW, Förster I, Schins RPF. Particles which may occur in food or food packaging can exert cytotoxicity and (oxidative) DNA damage in target cells of the human intestine. Letter to the editor. Nanotoxicology 5: 282-283, 2011.

Loft S, Schins RPF, Møller P: Particulates and oxidative stress. In: Cardiovascular Effects of Inhaled Ultrafine and Nano-Sized Particles. Cassee FR, Mills NL, Newby DE (Eds). John Wiley and Sons, New Jersey, USA , pp. 251-271, 2011.


Weissenberg A*, Sydlik U*, Peuschel H, Schroeder P, Schneider M, Schins RP, Abel J, Unfried K: Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles. Free Radic Biol Med 49: 597–605, 2010. (*equal contribution)

van Berlo D, Wessels A, Boots A, Wilhelmi V, Scherbart A, Gerloff K, van Schooten FJ, Albrecht C, Schins R: Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles. Free Radic Biol Med  49(11):1685-93, 2010.

Wessels A, Birmili W, Albrecht C, Hellack B, Jermann E, Wick G, Harrison RM, Schins RPF: Oxidant generation and toxicity of size-fractionated ambient particles in A549 human lung epithelial cells. Environ Sci Technol 44 (9): 3539-3545, 2010.

Demircigil Cakmak G, Coskun E, Vidinli N, Erbas Y, Yilmaz M, Cimrin A, Schins RPF, Borm PJA, Burgaz S: Increased micronucleus frequencies in surrogate and target cells from workers exposed to crystalline silica containing dust.
Mutagenesis 25: 163-169, 2010.

van Berlo D, Albrecht C,  Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ, Krutmann J, Schins RPF: Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch Toxicol 84 (7): 553-562, 2010.

Orru H, Kimmel V, Kikas Ü, Soon A, Künzli N, Schins RPF, Borm PJA, Forsberg B: Elemental Composition and Oxidative Properties of PM2.5 in Estonia in Relation of Origin of Air Masses - results from ERCHS II in Tartu. Sci Tot Environ 408 (7): 1515-1522, 2010.

Gerlofs-Nijland M, van Berlo D, Cassee FR, Schins RPF, Wang K, Campbell A: Effects of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol 7 (1): 12, 2010.

van Berlo D, Knaapen AM, van Schooten FJ, Schins RP, Albrecht C: NF-kappaB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells. Part Fibre Toxicol 7 (1): 13, 2010.

Donaldson K, Poland C, Schins RPF: Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies. Nanotoxicology 4: 414-420, 2010.


Gerlofs-Nijland ME, Rummelhard M, Boere JF, Leseman DLAC, Duffin R, Schins RPF, Borm PJA, Sillanpää M, Salonen RO, Cassee FR: Particle induced toxicity in relation to Transition Metal and Polycyclic Aromatic Hydrocarbon contents. Environ Sci Technol 43 (13): 4729-4736, 2009.

Gerloff K, Albrecht C, Boots AW, Förster I, Schins RPF: Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology 3 (4): 355-364,  2009.

Van Berlo D, Haberzettl P, Gerloff K, Li H, Scherbart AM, Albrecht C, Schins RPF: Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macropages. Chemical Research in Toxicology 22 (9): 1548-1558, 2009.

Baulig A, Singh S, Marchand A, Schins R, Barouki R, Garlatti M, Marano F, Baeza-Squiban A: Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells. Toxicology 261 (3): 126-135, 2009.

Herberth G, Gubelt R, Röder S, Krämer U, Schins RP, Diez U, Borte M, Heinrich J, Wichmann HE, Herbarth O, Lehmann I: Increase of inflammatory markers after indoor renovation activities: The LISA birth cohort study. Pediatr Allergy Immunol 20 (6): 563-570, 2009.

Albrecht C, Scherbart AM, Berlo D, Braunbarth CM, Schins RPF, Scheel J: Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite dispersions of different physicochemical properties in rat NR8383 cells and primary macrophages. Toxicology in Vitro 23 (3): 520-530, 2009.

Jalava PI, Hirvonen MR, Sillanpää M, Pennanen AS, Happo MS, Hillamo R, Cassee FR, Gerlofs-Nijland M, Borm PJ, Schins RP, Janssen NA, Salonen RO: Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line. Inhalation Toxicology 21 (12): 994-1006, 2009.

Bhattacharya K, Davoren M, Boertz J, Schins RP, Hoffmann E, Dopp E: Titanium dioxide nanoparticles induce oxidative stress and DNA adduct formation but not DNA breakage in human lung cells. Part Fibre Toxicol 6 (1): 17, 2009.

Stone V, Johnston H, Schins RPF: Development of in vitro systems for Nanotoxicology – Methodological Considerations. Crit Rev Toxicol 39 (7), 613-626, 2009.


Mroz RM, Schins RPF, Li H, Jimenez LA, Drost EM, Holownia A, MacNee W, Donaldson K: Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways. Eur Respir J 31: 241-251, 2008.

Haberzettl P, Schins RPF, Höhr D, Wilhelmi V, Borm PJA, AlbrechtC: Impact of the FcgammaII-receptor on quartz uptake and inflammatory response by alveolar macrophages. Am J Physiol – Lung Cell Mol Biol 294 (6): L1137-1148, 2008.

Papageorgiou I, Shadrick V, Davis S, Hails L, Schins RPF, Newson R, Fisher J, Ingham E, Case CP: Macrophages detoxify the genotoxic and cytotoxic effectsd of surgical cobal chrome alloy particles but not quartz particles on human cells in vitro. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 643 (1-2): 11-19, 2008.

Li H, van Berlo D, Shi T, Speit G, Knaapen AM, Borm PJA, Albrecht C, Schins RPF: Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Tox Appl Pharmacol  227:115-124, 2008.

Bhattacharya K, Cramer H, Albrecht C, Schins R, Rahman Q, Zimmermann U, Dopp E: Vanadium pentoxide coated ultrafine titanium dioxide particles induce cellular damage and micronucleus formation in V79-cells. J Toxicol Environ Health A 71: 976-980, 2008.


Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, Fisher J, Ingham E, Case CP: The effect of nano- and micron-sized particles of cobalt chromium alloy on human fibroblasts in vitro. Biomaterials28 (19): 2946-2958, 2007.

Boots AW, Li H, Schins RP, Duffin R, Heemskerk JWM , Bast A, Haenen GR: The quercetin paradox. Toxicology and Applied Pharmacology 222: 89-96, 2007.

Singh S, Shi T, Duffin R, Albrecht C, van Berlo D, Höhr D, Fubini B, Martra G, Fenoglio I, Borm PJA, Schins RPF: Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles. Toxicology and Applied Pharmacology 222: 141-151, 2007.

Godschalk RW, Albrecht C, Curfs DMJ, Schins RPF, Bartsch H, van Schooten FJ, Nair J: Decreased levels of lipid peroxidation induced DNA damage in early atherogenesis in apolipoprotein E- knockout mice. Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis 621(1-2): 87-94, 2007.

Li H, Haberzettl P, Albrecht C, Höhr D, Knaapen AM, Borm PJA, Schins RPF: Inhibition of the mitochondrial respiratory chain function abrogates quartz induced DNA damage in lung epithelial cells. Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis 617 (1-2), 46-57, 2007.

Mroz RM, Schins RPF, Li H, Drost EM, MacNee W, Donaldson K: Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line. J Physiol Pharmacol 58 (suppl. 5), 461-470, 2007.

Albrecht C, Höhr D, Haberzettl, Becker A, Borm PJA, Schins RPF: Surface-dependent quartz-uptake by macrophages: potential role in pulmomonary inflammation and lung clearance. Inhalation Toxicology 19 (1): 39-48, 2007.

Haberzettl P, Duffin R, Krämer U, Höhr D, Schins R, Borm PJA, Albrecht C: Actin plays a crucial role in the phagocytosis and biological responses to respirable quartz particles in macrophages. Archives of Toxicology 81 (7): 459-470, 2007.

Borm PJA, Kelly F, Künzli N, Schins RPF, Donaldson K: Oxidant generation by particulate matter: from biologically effective dose to a promising, novel metric. Occup Environ Med 64(2): 73-74, 2007.

Unfried K, Albrecht C, Klotz LO, von Mikecz A, Grether-Beck S, Schins RPF: Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1: 52-71, 2007.

Schins RPF, Knaapen AM: Genotoxicity of poorly soluble particles. Inhal Toxicol 19(1) 189-198, 2007.


Sydlik U, Bierhals K, Soufi M, Abel J, Schins R, Unfried K: Ultrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-R. Am J Physiol Lung Cell Mol Physiol 291 (4): L725-L733, 2006.

Herberth G, Daegelmann C, Weber A, Roder S, Giese T, Kramer U, Schins RP, Behrendt H, Borte M, Lehmann I; for the LISAplus study group: Association of neuropeptides with Th1/Th2 balance and allergic sensitization in children. Clin Exp Allergy 36 (11): 1408-1416, 2006.

Øvrevik J, Hetland RB, Schins PRF, Myran T, Schwarze PE: Iron release and ROS-generation from mineral particles are not related to cytokine release or apoptosis in exposed A549 cells. Toxicol Letters 165 (1) 31-38, 2006.

Shi T, Duffin R, Borm PJA, Li H, Weishaupt C, Schins RPF: Involvement of hydroxyl radical generation in particulate matter induced DNA damage. Environ Res 101 (1): 18-24, 2006.

Geh S, Shi T, Shokouhi B, Schins RPF, Armbruster L, Rettenmeier AW, Dopp E: Genotoxic potential of respirable bentonite particles with different quartz contents and chemical modifications in human lung fibroblasts. Inhalation Toxicology 18 (6): 405-412, 2006.

Becker A, Albrecht C, Schins RPF, Höhr D, Ledermann K, Knaapen AM, Borm PJA: Induction of CYP1A1 in rat lung cells following in vivo and in vitro exposure to quartz. Archives of Toxicology 80 (5): 258-268, 2006.

Borm PJA, Schins RPF: Toxicological characterization of engineered nanoparticles. In: Nanoparticle Technology for Drug Delivery. Eds. RB Gupta, UB Kompella. New York: Marcel Dekker 2006, pp. 161-197.

Borm PJA , Robbins R, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins RPF, Stone V, Kreyling W, Lademann J, Krutmann J, Warheit D, Oberdorster E: The potential risks of nanomaterials: a review carried out for ECETOC. Particle and Fibre Toxicology 3:11, 2006.

Knaapen AM, Güngör N, Schins RPF, Borm PJA, van Schooten FJ: Neutrophils and respiratory tract DNA damage and mutagenesis: a review.  Mutagenesis 21, 225-236, 2006.

Schins RPF, Hei TK: Genotoxic Effects of Particles. In: Particle toxicology (Eds: Donaldson K, Borm P). Boca Raton, CRC Press/Taylor & Francis Group 2006, pp. 285-298.