Aktuelle Publikationen

Originalarbeiten

Liu Y, Gao W, Koellmann C, Le Clerc S, Hüls A, Li B, Peng Q, Wu S, Ding A, Yang Y, Jin L, Krutmann J, Schikowski T, Zagury JF, Wang S: Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. J Dermatol Sci 2019. doi: 10.1016/j.jdermsci.2019.08.010

Walter KM*, Dach K*, Hayakawa K*, Giersiefer S, Heuer H, Lein PJ#, Fritsche E#: Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. Plos One 14(9): e0221230, 2019. doi: 10.1371/journal.pone.0221230

Grether-Beck S, Marini A, Jaenicke T, Goessens-Rück P, McElwee KJ,  Hoffmann R, Krutmann J: Autologous cell therapy for aged human skin: a randomized, placebo-controlled, phase-I study. Skin Pharmacol Physiol 2019. doi: 10.1159/000502240

Jorcano A, Lubczyńska MJ, Pierotti L, Altug H, Ballester F, Cesaroni G, El Marroun H, Fernández-Somoano A, Freire C, Hanke W, Hoek G, Ibarluzea J, Iñiguez C, Jansen PW, Lepeule J, Markevych I, Polańska K, Porta D, Schikowski T, Slama R, Standl M, Tardon A, Vrijkotte TGM, von Berg A, Tiemeier H, Sunyer J, Guxens M: Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts. Environ Int 2019 131: 104927, 2019. doi: 10.1016/j.envint.2019.104927

Harris CP, von Berg A, Berdel D, Bauer CP, Schikowski T, Koletzko S, Heinrich J, Schulz H, Standl M: Dietary saturated fat and low-grade inflammation modified by accelerometer-measured physical activity in adolescence: results from the GINIplus and LISA birth cohorts. BMC Public Health 19(1): 818, 2019. doi: 10.1186/s12889-019-7113-6

Soppa VJ, Shinnawi S, Hennig F, Sasse B, Hellack B, Kaminski H, Quass U, Schins RPF, Kuhlbusch TAJ, Hoffmann B: Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness – a randomized sham-controlled exposure study. Int J Hyg Environ Health 222(8): 1115-1132, 2019. doi: 10.1016/j.ijheh.2019.08.002

Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N: Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11(16): 6535-6554, 2019. doi: 10.18632/aging.102208

Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H, Wang CC: Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines. Reprod Toxicol 89: 45-53, 2019. doi: 10.1016/j.reprotox.2019.06.001

Trullàs C, Granger C, Lim HW, Krutmann J, Masson P: Linear and exponential sunscreen behaviours as an explanation for observed discrepancies in sun protection factor testing. Photodermatol Photoimmunol Photomed 2019. doi: 10.1111/phpp.12500

Granger C, Krutmann J, Bustos J, Sola Y, Hosenally M, Trullàs C, Andres P, Passeron T: New methodology to evaluate sunscreens under outdoor conditions: A double-blind, randomized intra-individual clinical study of a water-based broad-spectrum SPF50+ versus SPF15 (P3) and SPF50+. Dermatol Ther  9(3): 589-599, 2019. doi: 10.1007/s13555-019-00315-4

Piechulek A, Berwanger L, von Mikecz A: Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium. Nanotoxicology 13(8): 1133-1148, 2019. doi: 10.1080/17435390.2019.1643048

Esser C, Hochrath K, Teichweyde N, Krutmann J, Chang H-D: Beyond sequencing: fast and easy microbiome profiling by flow cytometry. Arch Toxicol 93(9): 2703-2704, 2019. doi: 10.1007/s00204-019-02527-1

Fiala GJ, Schaffer AM, Merches K, Morath A, Swann J, Herr LA, Hils M, Esser C, Minguet S, Schamel WWA: Proximal Lck promoter-driven Cre function is limited in neonatal and ineffective in adult γδ T cell development. J Immunol 203(2): 569-579, 2019. doi: 10.4049/jimmunol.1701521

Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW: 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1: 546-559, 2019. doi: 10.1038/s42255-019-0055-6

Ishihara Y, Haarmann-Stemmann T, Kado N, Vogel CFA: Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages. Toxicol Sci 170(2): 404-414, 2019. doi: 10.1093/toxsci/kfz114

Piechulek A, von Mikecz A: Aging by pollutants: Introducing the aging dose (AD)50. Environ Sci Eur 31: 23, 2019. doi: 10.1186/s12302-019-0205-1

Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T*, Homey B*, Meller S*: Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events. Allergy 2019. doi: 10.1111/all.13972

Mescher M, Tigges J, Rolfes KM, Shen AL, Yee J, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T: The toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver. Archiv Toxicol 93(7): 1917-1926, 2019. doi: 10.1007/s00204-019-02488-5

Fuks KB, Wigmann C, Altug H, Schikowski T: Road traffic noise at the residence, annoyance, and cognitive function in elderly women. Int J Environ Res Public Health 16(10): 1790, 2019. doi: 10.3390/ijerph16101790

Weigel C, Chaisaingmongkol J, Assenov Y, Kuhmann C, Winkler V, Santi I, Bogatyrova O, Kaucher S, Bermejo JL, Leung SY, Chan TL, Lasitschka F, Bohrer MH, Marx A, Haußen RH, Herold-Mende C, Dyckhoff G, Boukamp P, Delank KW, Hörmann K, Lippert BM, Baier G, Dietz A, Oakes CC, Plass C, Becher H, Schmezer P, Ramroth H, Popanda O: DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. Clin Epigenetics 11(1): 67, 2019. doi: 10.1186/s13148-019-0666-5

Masjosthusmann S, Siebert C, Hübenthal U, Bendt F, Baumann J, Fritsche E: Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense. Chemosphere 235: 447-456, 2019. doi: 10.1016/j.chemosphere.2019.06.123

Gonnissen S*, Ptok J*, Goy C, Jander K, Jakobs P, Eckermann O, Kaisers W, von Ameln F, Timm J, Ale-Agha N, Haendeler J#, Schaal H#, Altschmied J#: High concentration of low-density lipoprotein results in disturbances in mitochondrial transcription and functionality in endothelial cells. Oxid Med Cell Longev 2019. doi: 10.1155/2019/7976382 (*equal contribution, #shared senior authorship)

Vogel CFA, Ishihara Y, Campbell C, Kado S, Nguyen-Chi A, Sweeney C, Pollet M, Haarmann-Stemmann T*, Tuscano JM*: A protective role of aryl hydrocarbon receptor repressor in inflammation and tumor growth. Cancers 1(5): 589, 2019. doi: 10.3390/cancers11050589 (*equal contribution)

Wooding DJ, Ryu MH, Hüls A, Lee AD, Lin DTS, Rider CF, Yuen ACY, Carlsten C: Particle depletion does not remediate acute effects of traffic-related air pollution and allergen: A randomized, double-blinded crossover study. Am J Respir Crit Care Med 2019. doi: 10.1164/rccm.201809-1657OC

Yang BY, Markevych I, Harris C, Standl M, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Dong GH, Heinrich J: High-sensitivity C-reactive protein and allergic endpoints in German adolescents. Int Arch Allergy Immunol 179(2): 152-157, 2019. doi: 10.1159/000497320

Guo Q, Liang F, Tian L, Schikowski T, Liu W, Pan X: Ambient air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing: a time-stratified case-crossover analysis. Environ Sci Process Impacts 21(1): 163-173, 2019. doi: 10.1039/c8em00494c

Groten K, Marini A, Grether-Beck S, Jaenicke T, Ibbotson SH, Moseley H, Ferguson J, Krutmann J: Tomato phytonutrients balance UV response: Results from a double blind, randomized, placebo controlled study. Skin Pharmacol Physiol 32(2): 101-108, 2019. doi: 10.1159/000497104

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F: The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun 10(1): 651, 2019. doi: 10.1038/s41467-019-08555-w

Hausmann C, Zoschke C, Wolff C, Darvin ME, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schäfer-Korting M: Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake. Sci Rep 9(1): 2913, 2019. doi: 10.1038/s41598-019-39770-6

Çakmak G, Ertürk Ari P, Emerce E, Arı A, Odabası M, Schins RPF, Burgaz S, Gaga EO: Investigation of spatial and temporal variation of particulate matter in vitro genotoxicity and cytotoxicity in relation to the elemental composition. Mutat Res Gen Tox En 842: 22-34, 2019. doi: 10.1016/j.mrgentox.2019.01.009

Hüls A, Sugiri D, Abramson MJ, Hoffmann B, Schwender H, Ickstadt K, Krämer U, Schikowski T: Benefits of improved air quality on aging lungs - Impacts of genetics and obesity. Eur Respir J 53: 1801780, 2019. doi: 10.1183/13993003.01780-2018

Tran B-H, Dao V-A, Bilstein A, Unfried K, Shah-Hosseini K, Mösges R: Ectoine-containing inhalation solution versus saline inhalation solution in the treatment of acute bronchitis and acute respiratory infections: A prospective, controlled, observational study. Biomed Res Int 2019: 7945091, 2019. doi: 10.1155/2019/7945091

Fuks K*, Hüls A*, Sugiri D, Altug H, Vierkötter A, Abramson M, Goebel J, Wagner G, Demuth I, Krutmann J*, Schikowski T*: Tropospheric ozone and skin aging: results from two German cohort studies. Environ Int 124: 139-144, 2019. doi: 10.1016/j.envint.2018.12.047 (* equal contribution)

Zhao T, Markevych I, Standl M, Schulte-Körne G, Schikowski T, Berdel D, Koletzko S, Bauer CP, von Berg A, Nowak D, Heinrich J: Ambient ozone exposure and depressive symptoms in adolescents: Results of the GINIplus and LISA birth cohorts. Environ Res 170: 73-81, 2019. doi: 10.1016/j.envres.2018.12.014

Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J: Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome amplified cancer cells. EMBO J 38(2): e99876, 2019. doi: 10.15252/embj.201899876

Steinbrenner H, Micoogullari M, Hoang NA, Bergheim I, Klotz L-O, Sies H: Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes. Redox Biol 20: 489-495, 2019. doi: 10.1016/j.redox.2018.11.004

Markevych I, Feng X, Astell-Burt T, Standl M, Sugiri D, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Heinrich J: Residential and school greenspace and academic performance: Evidence from the GINIplus and LISA longitudinal studies of German adolescents. Environ Pollut 245: 71-76, 2019. doi: 10.1016/j.envpol.2018.10.053

Spannbrucker T*, Ale-Agha N*, Goy C, Dyballa-Rukes N, Jakobs P, Jander K, Altschmied J, Unfried K, Haendeler J: Induction of a senescent like phenotype and loss of gap junctional intercellular communication by carbon nanoparticle exposure of lung epithelial cells. Exp Gerontol 117: 106-112, 2019. doi: 10.1016/j.exger.2018.11.017 (*equal contribution)

Hüls A*, Abramson MJ*, Sugiri D, Fuks K, Krämer U, Krutmann J, Schikowski T: Non-atopic eczema in elderly women - Impact of air pollution and genes. J Allergy Clin Immunol 143(1): 378-385.e9, 2019. doi: 10.1016/j.jaci.2018.09.031 (* equal contribution)

Kühne BA, Puig T, Ruiz-Martínez S, Crous-Masó J, Planas M, Feliu L, Cano A, Garcia ML, Fritsche E, Llobet JM, Gómez-Catalán J, Barenys M: Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres. Food Chem Toxicol 123: 195-204, 2019. doi: 10.1016/j.fct.2018.10.055

Hüls A, Sugiri D, Fuks K, Krutmann J*, Schikowski T*: Lentigines formation in Caucasian women - Interaction between particulate matter and solar UVR. J Invest Dermatol 139(4): 974-976, 2019. doi: 10.1016/j.jid.2018.09.034 (* equal contribution)

Ali AAH, Schwarz-Herzke B, Mir S, Sahlender B, Victor M, Görg B, Schmuck M, Dach K, Fritsche E, Kremer A, von Gall C: Deficiency of the clock gene Bmal1 affects neural progenitor cell migration. Brain Struct Funct 224(1): 373-386, 2019. doi: 10.1007/s00429-018-1775-1

Übersichtsarbeiten, Buchbeiträge u.a.

Pavan C, Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison D, Lo Giudice C, Martra G, Montfort E, Schins RPF, Sulpizi M, Wegner K, Wyart-Remy M, Ziemann C, Turci F: The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity? Part Fibre Toxicol 16(1): 32, 2019. doi: 10.1186/s12989-019-0315-3

Solecki R, Rauch M, Gall A, Buschmann J, Kellner R, Kucheryavenko O, Schmitt A, Delrue N, Li W, Hu J, Fujiwara M, Kuwagata M, Mantovani A, Makris SL, Paumgartten F, Schönfelder G, Schneider S, Vogl S, Kleinstreuer N, Schneider M, Schulze F, Fritsche E, Clark R, Shiota K, Chahoud I: Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol 89: 124-129, 2019. doi:
10.1016/j.reprotox.2019.07.003

Bernard JJ, Gallo RL, Krutmann J: Photoimmunology: how ultraviolet radiation affects the immune system. Nat Rev Immunol 2019. doi: 10.1038/s41577-019-0185-9

Gopalakrishnan J: The emergence of stem cell-based brain organoids: Trends and challenges. Bioessays 2019. doi: 10.1002/bies.201900011

Bruckmann P, Krämer U, Wichmann HE: Wissenschaft trifft Politik - die Basis der europäischen Grenzwerte für Stickstoffdioxid und Feinstaub. Umwelt - Hygiene – Arbeitsmed 24(2): 83-100, 2019.

Krutmann J: Luftverschmutzung und Haut. Hautarzt 70(3): 156-157, 2019. doi: 10.1007/s00105-018-4349-5

Krämer U, Behrendt H: Luftverschmutzung und atopisches Ekzem. Hautarzt 70(3): 169-184, 2019. doi: 10.1007/s00105-018-4330-3

Schikowski T, Krutmann J: Luftverschmutzung (Feinstaub, Stickstoffdioxid) und Hautalterung. Hautarzt 70(3): 158-162, 2019. doi: 10.1007/s00105-018-4338-8 (Leitthema)

Fuks KB, Woodby B, Vallacchi G: Hautschäden durch troposphärisches Ozon. Hautarzt 70(3): 163-168, 2019. doi: 10.1007/s00105-018-4319-y (Leitthema)

Reinke H, Asher G: Crosstalk between metabolism and circadian clocks. Nat Rev Mol Cell Biol 20: 227-241, 2019. doi: 10.1038/s41580-018-0096-9