AG Haendeler - Publikationen


Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW: 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1: 546-559, 2019. doi: 10.1038/s42255-019-0055-6

Gonnissen S*, Ptok J*, Goy C, Jander K, Jakobs P, Eckermann O, Kaisers W, von Ameln F, Timm J, Ale-Agha N, Haendeler J#, Schaal H#, Altschmied J#: High concentration of low-density lipoprotein results in disturbances in mitochondrial transcription and functionality in endothelial cells. Oxid Med Cell Longev 2019: 7976382, 2019. doi: 10.1155/2019/7976382 (*equal contribution, #shared senior authorship)

Spannbrucker T*, Ale-Agha N*, Goy C, Dyballa-Rukes N, Jakobs P, Jander K, Altschmied J, Unfried K, Haendeler J: Induction of a senescent like phenotype and loss of gap junctional intercellular communication by carbon nanoparticle exposure of lung epithelial cells. Exp Gerontol 117: 106-112, 2019. doi: 10.1016/j.exger.2018.11.017 (*equal contribution)


Nguyen TD, Schwarzer M, Schrepper A, Amorim PA, Blum D, Hain C, Faerber G, Haendeler J, Altschmied J, Doenst T: Increased Protein Tyrosine Phosphatase 1B (PTP1B) activity and cardiac insulin resistance precede mitochondrial and contractile dysfunction in pressure-overloaded hearts. J Am Heart Assoc 7 (13): e008865, 2018. doi: 10.1161/JAHA.118.008865

Ale-Agha N#, Goy C#, Jakobs P#, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Köhrer K, Deenen R, Unfried K, Altschmied J*, Haendeler J*: CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system - New mode of action for caffeine. Plos Biol 16(6): e2004408. doi: 10.1371/journal.pbio.2004408 (#, * equal contribution)

Kotz S, Kullmann M, Kalayda GV, Dyballa-Rukes N, Jaehde U, Metzger S: Optimized two-dimensional gel electrophoresis in an alkaline pH range improves the identification of intracellular CFDA-cisplatin-protein adducts in ovarian cancer cells. Electrophoresis 39(12): 1488-1496, 2018. doi: 10.1002/elps.201700377

Stöckmann D, Spannbrucker T, Ale-Agha N, Jakobs P, Goy C, Dyballa-Rukes N, Hornstein T, Kümper A, Kraegeloh A, Haendeler J, Unfried K: Non-canonical activation of the epidermal growth factor receptor by carbon nanoparticles. Nanomaterials 8(4): 267, 2018. doi: 10.3390/nano8040267

Hendgen-Cotta UB, Esfeld S, Jastrow H, Totzeck M, Altschmied J, Goy C, Haendeler J, Winterhager E, Rassaf T: Mouse cardiac mitochondria do not separate in subsarcolemmal and interfibrillar subpopulations. Mitochondrion 38: 1-5, 2018. doi: 10.1016/j.mito.2017.07.005

Heiss C, Spyridopoulos I, Haendeler J: Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules. Exp Gerontol 109: 108-118, 2018. doi: 10.1016/j.exger.2017.06.015


Papala A, Sylvester M, Dyballa-Rukes N, Metzger S, D'Haese J: Isolation and characterization of human CapG expressed and post-translationally modified in Pichia pastoris. Protein Expr Purif 134: 25-37, 2017. doi: 10.1016/j.pep.2017.03.017

Gödecke A, Haendeler J: Intra- and interorgan communication in the cardiovascular system: a special view on redox regulation. Antioxid Redox Signal 26(12): 613-615, 2017. doi: 10.1089/ars.2017.6988

Dyballa-Rukes N*, Jakobs P*, Eckers A*, Ale-Agha N, Serbulea V, Aufenvenne K, Zschauer TC, Rabanter LL, Jakob S, von Ameln F, Eckermann O, Leitinger N, Goy C, Altschmied J#, Haendeler J#: The anti-apoptotic properties of APEX1 in the endothelium require the first twenty amino acids and converge on Thioredoxin-1. Antioxid Redox Signal 26(12): 616-629, 2017. doi: 10.1089/ars.2016.6799 (*,# equal contribution)

Kohlgrüber S, Upadhye A, Dyballa-Rukes N, McNamara CA, Altschmied J: Regulation of transcription factors by reactive oxygen species and nitric oxide in vascular physiology and pathology. Antioxid Redox Signal 26(13): 679-699, 2017. doi: 10.1089/ars.2016.6946

Jakobs P*, Serbulea V*, Leitinger N, Eckers A#, Haendeler J#: Nuclear factor (erythroid-derived 2)-like 2 and Thioredoxin-1 in atherosclerosis and ischemia/reperfusion injury in the heart. Antioxid Redox Signal 26(12): 630-644, 2017. doi: 10.1089/ars.2016.6795 (*,# equal contribution)


Zurek M*, Altschmied J*, Kohlgrüber S, Ale-Agha N, Haendeler J: Role of Telomerase in the cardiovascular system. Genes 7(6): 29, 2016. doi: 10.3390/genes7060029 (* equal contribution)

Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H, Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP: MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4. Aging 8(3): 484-509, 2016. doi: 10.18632/aging.100905

Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N, Haendeler J: The aryl hydrocarbon receptor promotes aging phenotypes. Sci Rep 6: 19618, 2016. doi: 10.1038/srep19618

De Spirt S, Eckers A, Wehrend C, Micoogullari M, Sies H, Stahl W, Steinbrenner H: Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2- regulated antioxidant enzymes in intestinal Caco-2 cells. Free Radic Biol Med  91: 164-171, 2016. doi: 10.1016/j.freeradbiomed.2015.12.011


Kullmann M, Kalayda GV, Hellwig M, Kotz S, Hilger AH, Metzger S, Jaehde U: Assessing the contribution of the two protein disulfide isomerases PDIA1 and PDIA3 to cisplatin resistance. J Inorg Biochem 153: 247-252, 2015. [pubmed]

Kotz S, Kullmann M, Crone B, Kalayda GV, Jaehde U, Metzger S: Combination of two-dimensional gel electrophoresis and a fluorescent carboxyfluorescein diacetate labeled cisplatin analogue allows the identification of intracellular cisplatin-protein adducts. Electrophoresis 36(21-22): 2811-2819. [pubmed]

Eckers A and Haendeler J: Endothelial cells in health and disease. Antioxid Redox Signal 22(14): 1209-1211, 2015. [pubmed]

Farrokh S*, Brillen AL*, Haendeler J, Altschmied J#, Schaal H#: Critical regulators of endothelial cell functions: for a change being alternative. Antioxid Redox Signal 22(14): 1212-1229, 2015. (*,# equal contribution) [pubmed]

Frauenstein K*, Tigges J*, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CFA*, Haarmann-Stemmann T*: Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol 89(8): 1329-1336. (* equal contribution) [pubmed]

Haendeler J, Czypiorski P, Altschmied J: Sektion I: Experimentelle Gerontologie – wie kann sie zur Implementierungswissenschaft beitragen. In: Hoben M, Bär M, Wahl H-W (Hrsg.): Implementierungswissenschaft für Pflege und Gerontologie. Grundlagen, Forschung und Anwendung - Ein Handbuch. Kohlhammer, Stuttgart, 2015. S. 371-373, ISBN 978-3-17-022612-8.

Eckers A, Dyballa-Rukes N, Farrokh S, Altschmied J, Haendeler J: Umweltinduzierte kardiovaskuläre Degeneration – Rolle von Grainyhead-like 3, Telomerase Reverse Transkriptase und Thioredoxin-1. Spitzenforschung Herz-Kreislauf Medizin. ALPHA-Informations-GmbH/Lampertheim, 2015. S. 28-42, ISSN: 1861-4620.


Theologidis I, Chelo IM, Goy C, Teotónio H: Reproductive assurance drives transitions to self-fertilization in experimental Caenorhabditis elegans. BMC Biol 12(1): 93, 2014. [pubmed]

Schuler D, Sansone R, Freudenberger T, Rodriguez-Mateos A, Weber G, Momma T, Goy C, Altschmied J, Haendeler J, Fischer JW, Kelm M, Heiss C: Measurement of endothelium-dependent vasodilation in mice. Arterioscler Thromb Vasc Biol 34(12): 2651-2657, 2014. [pubmed]

Czypiorski P*, Altschmied J*, Rabanter LL, Goy C, Jakob S, Haendeler J: Outfielders playing in the infield: functions of aging-associated "nuclear" proteins in the mitochondria. Curr Mol Med 14(10): 1247-1251, 2014. (* equal contribution) [pubmed]

Goy C, Czypiorski P, Altschmied J, Jakob S, Rabanter L, Brewer AC, Ale-Agha N, Dyballa-Rukes N, Shah AM, Haendeler J: The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4. Exp Gerontol 56: 45-52, 2014. [pubmed]

Autengruber A, Sydlik U, Kroker M, Hornstein T, Ale-Agha N, Stöckmann D, Bilstein A, Albrecht C, Paunel-Görgülü A, Suschek CV, Krutmann J, Unfried K: Signalling-dependent adverse health effects of carbon nanoparticles are prevented by the compatible solute beta mannosylglycerate (firoin) in vitro and in vivo. Plos one 9(11): e111485, 2014. [pubmed]

Ale-Agha N, Dyballa-Rukes N, Jakob S, Altschmied J, Haendeler J: Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase - Potential role in senescence and aging. Exp Gerontol 56: 189-193, 2014. [pubmed]

Dyballa-Rukes N, Schuh C, Vogt H, Toma O, Schlack WS, Weber NC, Metzger S: In vivo desflurane preconditioning evokes dynamic alterations of metabolic proteins in the heart - proteomic insights strengthen the link between bioenergetics and cardioprotection. Cell Physiol Biochem 33: 967-981, 2014. [pubmed]

Carvalho S, Chelo IM, Goy C, Teotónio H: The role of hermaphrodites in the experimental evolution of increased outcrossing rates in Caenorhabditis elegans. BMC Evol Biol 14: 116, 2014. [pubmed]

Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F: The Hallmarks of Fibroblast Ageing. Mech Ageing Dev 138: 26-44, 2014. [pubmed]


Burgoyne JR, Oka S, Ale-Agha N, Eaton P: Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system. Antioxid Redox Signal 18(9): 1042-1052, 2013. [pubmed]

Zschauer TC, Matsushima S, Altschmied J, Shao D, Sadoshima J, Haendeler J: Interacting with Thioredoxin-1 - disease or no disease? Antioxid Redox Signal 18(9): 1053-1062, 2013. [pubmed]

Haendeler J, Mlynek A, Büchner N, Lukosz M, Graf M, Güttler C, Jakob S, Farrokh S, Kunze K, Goy C, Guardiola-Serrano F, Schaal H, Cortese-Krott M, Deenen R, Köhrer K, Winkler C, Altschmied J: Two isoforms of sister-of-mammalian grainyhead have opposing functions in endothelial cells and in vivo. Arterioscler Thromb Vasc Biol 33: 1639-1646, 2013. [pubmed]

Büchner N, Ale-Agha N, Jakob S, Sydlik U, Kunze K, Unfried K, Altschmied J, Haendeler J: Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes. Exp Gerontol 48(1): 8-16, 2013. [pubmed]

Czypiorski P, Rabanter LL, Altschmied J, Haendeler J: Redox balance in the aged endothelium. Z Gerontol Geriatr 46(7): 635-638, 2013. [pubmed]

Stolzing A, Haendeler J: Aging – Mechanisms, Models and Translation. Z Gerontol Geriatr 46 (7): 612, 2013.


Peuschel H, Sydlik U, Grether-Beck S, Felsner I, Stöckmann D, Jakob S, Kroker M, Haendeler J, Gotic M, Bieschke C, Krutmann J, Unfried K: Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation. Part Fibre Toxicol 9(1): 48, 2012. [pubmed]

Haendeler J, Eckers A, Lukosz M, Unfried K, Altschmied J: Endothelial NADPH oxidase 2 – when does it matter in atherosclerosis? Cardiovasc Res 94(1): 1-2, 2012.

Shao D, Oka S, Brady CD, Haendeler J, Eaton P, Sadoshima J: Redox modification of cell signaling in the cardiovascular system. J Mol Cell Cardiol 52(3): 550-558, 2012. [pubmed]

Eckers A, Altschmied J, Haendeler J: Oxidativer Stress im Endothel und bei Diabetes Typ 2. Z Gerontol Geriatr 45(2): 90-94, 2012. [pubmed]


Zschauer TC, Kunze K, Jakob S, Haendeler J, Altschmied J: Oxidative stress-induced degradation of Thioredoxin-1 and apoptosis is Iinhibited by Thioredoxin-1-actin interaction in endothelial cells. Arterioscler Thromb Vasc Biol 31(3): 650-656, 2011. [pubmed]

Werner C, Gensch C, Pöss J, Haendeler J, Böhm M, Laufs U: Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis. Atherosclerosis 216 (1): 23-34, 2011. [pubmed]

Eckers A, Sauerbier E, Anwar-Mohamed A, Hamann I, Esser C, Schroeder P, El-Kadi AO, Klotz LO: Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct. Arch Biochem Biophys 516 (2): 138-145, 2011. [pubmed]

Lukosz M, Mlynek A, Czypiorski P, Altschmied J, Haendeler J: The transcription factor Grainyhead like 3 (GRHL3) affects endothelial cell apoptosis and migration in a NO-dependent manner. Biochem Biophys Res Commun 412 (4): 648-553, 2011. [pubmed]


Seeger FH, Sedding D, Langheinrich A, Chen-Wichmann L, Haendeler J, Zeiher AM, Dimmeler S: Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression. Basic Res Cardiol 110: 389-397, 2010.

Büchner N, Zschauer TC, Lukosz M, Altschmied J, Haendeler J: Downregulation of mitochondrial Telomerase Reverse Transcriptase induced by H2O2 is Src kinase dependent. Exp Gerontol 45 (7-8): 558-562, 2010.

Peuschel H, Sydlik U, Haendeler J, Büchner N, Stökmann D, Kroker M, Wirth R, Brock W, Unfried K: c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategy. Biol Chem 391 (11): 1327-1332, 2010.

Buechner N, Altschmied J, Jakob S, Saretzki G, Haendeler J: Well-known signalling proteins exert new functions in the nucleus and mitochondria. Antioxid Redox Signal 13 (4): 551-558, 2010.

Lukosz M, Jakob S, Buechner N, Zschauer TC, Altschmied J, Haendeler J: Nuclear redox signaling. Antioxid Redox Signal 12 (6): 713-742, 2010.


Werner CM, Fürster T, Widmann T, Pöss J, Roggia C, Hanhoun M, Scharhag J, Büchner N, Meyer T, Kindermann W, Haendeler J, Böhm M, Laufs U: Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation 120: 2438-2447, 2009.

Haendeler J, Dröse S, Büchner N, Jakob S, Altschmied J, Goy C, Spyridopoulos I, Zeiher AM, Brandt U, Dimmeler S: Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol 29 (6): 929-935, 2009.

Sopjani M, Föller M, Haendeler J, Götz F, Lang F: Silver ion-induced suicidal erythrocyte death. J Appl Toxicol 29 (6): 531-536, 2009.

Jakob S, Altschmied J*, Haendeler J*: “Shping 2” different cellular localizations - a potential new player in aging processes. Aging 1, 664-668, 2009. (*equally contributed senior authors)

Koyanagi M, Iwasaki M, Haendeler J, Leitges M, Zeiher AM, Dimmeler S: Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation. PLoS One 4(6): e5765, 2009.

Altschmied J, Haendeler J: Thioredoxin-1 and endothelial cell aging: Role in cardiovascular diseases. Antioxid Redox Signal 11, 1733-1740, 2009.


Werner C, Hanhoun M, Widmann T, Kazakov A, Semenov A, Pöss J, Bauersachs J, Thum T, Pfreundschuh M, Müller P, Haendeler J, Böhm M, Laufs U: Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis. J Am Coll Cardiol 52: 470-482, 2008.

Spyridopoulos I, Erben Y, Brummendorf TH, Haendeler J, Dietz K, Seeger F, Kissel C, Martin H, Hoffmann J, Assmus B, Zeiher AM, Dimmeler S: Telomere Gap Between Granulocytes and Lymphocytes Is a Determinant for Haematopoetic Progenitor Cell Impairment in Patients With Previous Myocardial Infarction. Arterioscler Thromb Vasc Biol 28 (5): 968-974, 2008.

Spyridopoulos I, Fichtlscherer S, Popp P, Toennes SW, Fisslthaler B, Trepels T, Zernecke A, Liehn EA, Weber C, Zeiher AM, Dimmeler S, Haendeler J: Caffeine enhances endothelial repair by an AMPK-dependent mechanism. Arterioscler Thromb Vasc Biol 28 (5): 1967-1974, 2008.

Jakob S, Schröder P, Lukosz M, Büchner N, Spyridopoulos I, Altschmied J*, Haendeler J*: Nuclear Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase: Implication for vascular aging. J Biol Chem 283: 33155-33161, 2008. (*contributed equally)

Nicolay JP, Liebig G, Niemoeller OM, Koka S, Ghashghaeinia M, Wieder T, Haendeler J, Busse R, Lang F: Inhibition of suicidal erythrocyte death by nitric oxide. Pflügers Arch 456 (2): 293-305, 2008.

Buechner N, Schroeder P, Jakob S, Kunze K, Maresch T, Calles C, Krutmann J, Haendeler J: Changes of MMP-1 and collagen type Ialpha1 by UVA, UVB and IRA are differentially regulated by Trx-1. Exp Gerontol 43: 633-637, 2008.

Schröder P, Haendeler J, Krutmann J: The role of near infrared radiation in photoaging of the skin. Exp Gerontol 43 (7): 629-632, 2008.

Guardiola-Serrano* F, Haendeler* J, Lukosz M, Sturm K, Von Melchner H, Altschmied J: Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration.  Biochem Biophys Res Commun 376: 748-752, 2008. (* contributed equally)

Altschmied J, Haendeler J: A new kid on the block: PKD1 – a promising target for anti-angiogenic therapy? (Editorial).  Arterioscler Thromb Vasc Biol 28: 1689-1690, 2008.

Haendeler J, Klotz LO: Highlight: Oxidative stress and senescence (Editorial). Biol. Chem. 389: 201, 2008.


Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S: SIRT1 controls endothelial angiogenic functions during vascular growth. Gene Dev 21: 2644-2658, 2007.

Fleming I, Rueben A, Popp R, Fisslthaler B, Schrodt S, Sander A, Haendeler J, Falck JR, Morisseau C, Hammock BD, Busse R: Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscler Thromb Vasc Biol 27 (12): 2612-26-18, 2007.

Schroeder P, Popp R, Wiegand B, Altschmied J, Haendeler J: Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells: Important role for nuclear thioredoxin-1.  Arterioscler Thromb Vasc Biol 27: 2325 – 2331, 2007.

Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J: Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. Arterioscler Thromb Vasc Biol 27(2): 275-282, 2007.

Jakob S, Haendeler J: Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase. Z Geriontol Geriat 40 (5): 334-338, 2007.

Sedding D, Haendeler J: Do we age on sirt1 expression? Editorial. Circulation Research 100 (10): 1396-1398, 2007.