Publikationen 2014

Originalarbeiten

Meijer M, Hendriks HS, Heusinkveld HJ, Langeveld WT, Westerink RH: Comparison of plate reader-based methods with fluorescence microscopy for measurements of intracellular calcium levels for the assessment of in vitro neurotoxicity. Neurotoxicology 45: 31-37, 2014. [pubmed]

Beelen R, Raaschou-Nielsen O, Stafoggia M, Jovanovic Andersen Z, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer P, Nieuwenhuijsen M, Vineis P, Xun WW, Katsouyanni K, Dimakopoulou K, Oudin A, Forsberg B, Modig L, Havulinna AS, Lanki T, Turunen A, Oftedal B, Nystad W, Nafstad P, De Faire U, Pedersen NL, Östenson CG, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Ellermann T, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita B, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Ineichen A, Schaffner E, Probst-Hensch N, Künzli N, Schindler C, Schikowski T, Adam M, Phuleria H, Vilier A, Clavel-Chapelon F, Declercq C, Grioni S, Krogh V, Tsai MY, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Katsoulis M, Trichopoulou A, Brunekreef B, Hoek G: Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. The Lancet 383(9919): 785-795, 2014. [pubmed]

Cesaroni G, Forastiere F, Stafoggia M, Andersen ZJ, Badaloni C, Beelen R, Caracciolo B, De Faire U, Erbel R, Eriksen KT, Fratiglioni L, Galassi C, Hampel R, Heier M, Hennig F, Hilding A, Hoffmann B, Houthuijs D, Jöckel KH, Korek M, Lanki T, Leander K, Magnusson PKE, Migliore E, Östenson CG, Overvad K: Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. BMJ 348: f7412, 2014. [pubmed] (open access)

Kälsch H, Hennig F, Moebus S, Möhlenkamp S, Dragano N, Jakobs H, Memmesheimer M, Erbel R, Jöckel KH, Hoffmann B; on behalf of the Heinz Nixdorf Recall Study Investigative Group: Are air pollution and traffic noise independently associated with atherosclerosis: the Heinz Nixdorf Recall Study. Eur Heart J 35(13): 853-860, 2014. [pubmed]

Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi MF, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl AA, Heimesaat MM, Esser C, Im SH, Radbruch A, Rutz S, Scheffold A: Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med 211(9): 1807-1819, 2014. [pubmed]

Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H: Transporters MCT8 and OATP1C1 maintain thyroid hormone homeostasis in the murine brain. J Clin Invest 124(5): 1987-1999, 2014. [pubmed]

Dimakopoulou K, Samoli E, Beelen R, Stafoggia M, Jovanovic Andersen Z, Hoffmann B, Fischer P, Nieuwenhuijsen M, Vineis P, Xun W, Hoek G, Raaschou-Nielsen O, Oudin A, Forsberg B, Modig L, Jousilahti P, Lanki T, Turunen A, Oftedal B, Nafstad P, Schwarze PE, Penell J, Fratiglioni L, Andersson N, Pedersen N, Korek M, De Faire U, Thorup Eriksen K, Tjønneland A, Becker T, Wang M, Bueno-de-Mesquita B, Tsai MY, Eeftens M, Peeters PH, Meliefste K, Marcon A, Krämer U, Kuhlbusch TA, Vossoughi M, Key T, de Hoogh K, Hampel R, Peters A, Heinrich J, Weinmayr G, Concin H, Nagel G, Ineichen A, Jacquemin B, Stempfelet M, Vilier A, Ricceri F, Sacerdote C, Pedeli X, Katsoulis M, Trichopoulou A, Brunekreef B, Katsouyanni K: Air pollution and non-malignant respiratory mortality in 16 cohorts within the ESCAPE project. Am J Respir Crit Care Med 189(6): 684-696, 2014. [pubmed]

Gruzieva O, Gehring U, Aalberse R, Agius R, Beelen R, Behrendt H, Bellander T, Birk M, de Jongste JC, Fuertes E, Heinrich J, Hoek G, Klümper C, Koppelman G, Korek M, Krämer U, Lindley S, Mölter A, Simpson A, Standl M, van Hage M, von Berg A, Wijga A, Brunekreef B, Pershagen G: Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts. J Allergy Clin Immunol 133(3): 767-776, 2014. [pubmed]

Sommer D, Peters A, Wirtz T, Mai M, Ackermann J, Thabet Y, Schmidt J, Weighardt H, Wunderlich FT, Degen J, Schultze JL, Beyer M: Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nat Commun 66C: 97-106, 2014. [pubmed]

Cai Y, Schikowski T, Adam M, Buschka A, Carsin AE, Jacquemin B, Marcon A, Sanchez M, Vierkötter A, Al-Kanaani Z, Beelen R, Birk M, Brunekreef B, Cirach M, Clavel-Chapelon F, Declercq C, de Hoogh K, de Nazelle A, Ducret-Stich RE, Valeria Ferretti V, Forsberg B, Gerbase MW, Hardy R, Heinrich J, Hoek G, Jarvis D, Keidel D, Kuh D, Nieuwenhuijsen MJ, Ragettli MS, Ranzi A, Rochat T, Schindler C, Sugiri D, Temam S, Tsai MY, Varraso R, Kauffmann F, Krämer U, Sunyer J, Künzli N, Probst-Hensch N, Hansell AL: Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts. Thorax 69(11): 1005-1014, 2014. [pubmed]

Theologidis I, Chelo IM, Goy C, Teotónio H: Reproductive assurance drives transitions to self-fertilization in experimental Caenorhabditis elegans. BMC Biol 12(1): 93, 2014. [pubmed] (open access)

Müller-Brandes C, Krämer U, Gappa M, Seitner-Sorge G, Hüls A, von Berg A, Hoffmann B, Schuster A, Illi S, Wisbauer M, Berdel D: LUNOKID: can numeric ATS/ERS quality criteria replace visual inspection of spirometry? Eur Respir J 43(5): 1347-1356, 2014. [pubmed]

Schikowski T, Mills IC, Anderson HR, Cohen A, Hansell A, Kauffmann F, Krämer U, Marcon A, Perez L, Sunyer J, Probst-Hensch N, Künzli N: Ambient air pollution - a cause for COPD? Eur Respir J 43(1): 250-263, 2014. [pubmed]

Schikowski T, Adam M, Marcon A, Cai Y, Vierkötter A, Carsin AE, Jacquemin B, Al Kanani Z, Beelen R, Birk M, Bridevaux PO, Brunekeef B, Burney P, Cirach M, Cyrys J, de Hoogh K, de Marco R, de Nazelle A, Declercq C, Forsberg B, Hardy R, Heinrich J, Hoek G, Jarvis D, Keidel D, Kuh D, Kuhlbusch T, Migliore E, Mosler G, Nieuwenhuijsen MJ, Phuleria H, Rochat T, Schindler C, Villani S, Tsai MY, Zemp E, Hansell A, Kauffmann F, Sunyer J, Probst-Hensch N, Krämer U, Künzli N: Association of ambient air pollution with the prevalence and incidence of COPD. Eur Respir J 44(3): 614-626, 2014. [pubmed]

Fuks KB, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, Oftedal B, Oudin A, Panasevich S, Penell J, Sommar JN, Sørensen M, Tiittanen P, Wolf K, Xun WW, Aguilera I, Basagaña X, Beelen R, Bots ML, Brunekreef B, Bueno-de-Mesquita HB, Caracciolo B, Cirach M, de Faire U, de Nazelle A, Eeftens M, Elosua R, Erbel R, Forsberg B, Fratiglioni L, Gaspoz JM, Hilding A, Jula A, Korek M, Krämer U, Künzli N, Lanki T, Leander K, Magnusson PK, Marrugat J, Nieuwenhuijsen MJ, Ostenson CG, Pedersen NL, Pershagen G, Phuleria HC, Probst-Hensch NM, Raaschou-Nielsen O, Schaffner E, Schikowski T, Schindler C, Schwarze PE, Søgaard AJ, Sugiri D, Swart WJ, Tsai MY, Turunen AW, Vineis P, Peters A, Hoffmann B: Arterial blood pressure and long-term exposure to traffic-related air pollution: An analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect 122(9): 896-905, 2014. [pubmed]

Hennig F, Fuks K, Moebus S, Weinmayr G, Memmesheimer M, Jakobs H, Bröcker-Preuss M, Führer-Sakel D, Möhlenkamp S, Erbel R, Jöckel KH, Hoffmann B: Association between source-specific particulate matter air pollution and hs-CRP: Local traffic and industrial emissions. Environ Health Perspect 122(7): 703-710, 2014. [pubmed]

Macintyre EA, Gehring U, Mölter A, Fuertes E, Klümper C, Krämer U, Quass U, Hoffmann B, Gascon M, Brunekreef B, Koppelman GH, Beelen R, Hoek G, Birk M, de Jongste JC, Smit H, Cyrys J, Gruzieva O, Korek M, Bergström A, Agius RM, de Vocht F, Simpson A, Porta D, Forastiere F, Badaloni C, Cesaroni G, Esplugues A, Fernández-Somoano A, Lerxundi A, Sunyer J, Cirach M, Nieuwenhuijsen MJ, Pershagen G, Heinrich J: Air pollution and respiratory infections during early childhood: An analysis of 10 European birth cohorts within the ESCAPE project. Environ Health Perspect 122(1): 107-113, 2014. [pubmed]

Macintyre EA, Brauer M, Melén E, Bauer CP, Bauer M, Berdel D, Bergström A, Brunekreef B, Chan-Yeung M, Klümper C, Fuertes E, Gehring U, Gref A, Heinrich J, Herbarth O, Kerkhof M, Koppelman GH, Kozyrskyj AL, Pershagen G, Postma DS, Thiering E, Tiesler CM, Carlsten C; TAG Study Group: GSTP1 and TNF gene variants and associations between air pollution and incident childhood asthma: The traffic, asthma and genetics (TAG) study. Environ Health Perspect 122(4): 418-424, 2014. [pubmed]

Stafoggia M, Cesaroni G, Peters A, Andersen ZJ, Badaloni C, Beelen R, Caracciolo B, Cyrys J, de Faire U, de Hoogh K, Eriksen KT, Fratiglioni L, Galassi C, Gigante B, Havulinna AS, Hennig F, Hilding A, Hoek G, Hoffmann B, Houthuijs D, Korek M, Lanki T, Leander K, Magnusson PK, Meisinger C, Migliore E, Overvad K, Ostenson CG, Pedersen NL, Pekkanen J, Penell J, Pershagen G, Pundt N, Pyko A, Raaschou-Nielsen O, Ranzi A, Ricceri F, Sacerdote C, Swart WJ, Turunen AW, Vineis P, Weimar C, Weinmayr G, Wolf K, Brunekreef B, Forastiere F: Long-term exposure to ambient air pollution and incidence of cerebrovascular events: Results from 11 European cohorts within the ESCAPE project. Environ Health Perspect 122(9): 919-925, 2014. [pubmed]

Wang M, Beelen R, Bellander T, Birk M, Cesaroni G, Cirach M, Cyrys J, de Hoogh K, Declercq C, Dimakopoulou K, Eeftens M, Eriksen KT, Forastiere F, Galassi C, Grivas G, Heinrich J, Hoffmann B, Ineichen A, Korek M, Lanki T, Lindley S, Modig L, Mölter A, Nafstad P, Nieuwenhuijsen MJ, Nystad W, Olsson D, Raaschou-Nielsen O, Ragettli M, Ranzi A, Stempfelet M, Sugiri D, Tsai MY, Udvardy O, Varró MJ, Vienneau D, Weinmayr G, Wolf K, Yli-Tuomi T, Hoek G, Brunekreef B: Performance of multi-city land use regression models for nitrogen dioxide and fine particles. Environ Health Perspect 122(8): 843-849, 2014. [pubmed]

Winneke G, Ranft U, Wittsiepe J, Kasper-Sonnenberg M, Fürst P, Krämer U, Seitner G, Wilhelm M: Behavioral sexual dimorphism in school-age children and early developmental exposure to dioxins and PCBs: a follow-up study of the Duisburg cohort. Environ Health Perspect 122(3): 292-298, 2014. [pubmed]

Zanobetti A, Luttmann-Gibson H, Horton ES, Cohen A, Coull BA, Hoffmann B, Schwartz JD, Mittleman MA, Li Y, Stone PH, de Souza C, Lamparello B, Koutrakis P, Gold DR: Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: A repeated-measures study. Environ Health Perspect 122(3): 242-248, 2014. [pubmed]

Peeters PM, Eurlings IMJ, Perkins TN, Wouters EF, Schins RPF, Borm PJA, Drommer W, Reynaert NL, Albrecht C: Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs. Particle and Fibre Toxicology 11(1): 58, 2014. [pubmed] (open access)

Tigges J*, Haarmann-Stemmann T*, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J*, Fritsche E: The new arylhydrocarbon receptor (AhR) antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one (BDDI) protects against UVB-induced signal transduction. J Invest Dermatol 134(2): 556-559, 2014. (* equal contribution) [pubmed] (open access)

Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen ZJ, Xun WW, Katsouyanni K, Dimakopoulou K, Brunekreef B, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Houthuijs D, Nieuwenhuijsen M, Oudin A, Forsberg B, Olsson D, Salomaa V, Lanki T, Yli-Tuomi T, Oftedal B, Aamodt G, Nafstad P, De Faire U, Pedersen NL, Östenson CG, Fratiglioni L, Penell J, Korek M, Pyko A, Eriksen KT, Tjønneland A, Becker T, Eeftens M, Bots M, Meliefste K, Wang M, Bueno-de-Mesquita B, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Cyrys J, Concin H, Nagel G, Ineichen A, Schaffner E, Probst-Hensch N, Dratva J, Ducret-Stich R, Vilier A, Clavel-Chapelon F, Stempfelet M, Grioni S, Krogh V, Tsai M-Y, Marcon A, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Katsoulis M, Trichopoulou A, Vineis P, Hoek G: Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 European cohorts within the ESCAPE project. Epidemiology 23(3): 368-378, 2014. [pubmed]

Eeftens M, Hoek G, Gruzieva O, Mölter A, Agius R, Beelen R, Brunekreef B, Custovic A, Cyrys J, Fuertes E, Heinrich J, Hoffmann B, de Hoogh K, Jedynska A, Keuken M, Klümper C, Kooter I, Krämer U, Korek M, Koppelman GH, Kuhlbusch TA, Simpson A, Smit HA, Tsai MY, Wang M, Wolf K, Pershagen G, Gehring U: Elemental composition of particulate matter and the association with lung function. Epidemiology 25(5): 648-657, 2014. [pubmed]

Gascon M, Sunyer J, Casas M, Martínez D, Ballester F, Basterrechea M, Bonde JP, Chatzi L, Chevrier C, Eggesbø M, Esplugues A, Govarts E, Hannu K, Ibarluzea J, Kasper-Sonnenberg M, Klümper C, Koppen G, Nieuwenhuijsen MJ, Palkovicova L, Pelé F, Polder A, Schoeters G, Torrent M, Trnovec T, Vassilaki M, Vrijheid M: Prenatal exposure to DDE and PCB 153 and respiratory health in early childhood: A meta-analysis. Epidemiology 25(4): 544-553, 2014. [pubmed]

Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, Beelen R, Cesaroni G, Chatzi L, de Agostini M, de Nazelle A, Eeftens M, Fernandez MF, Fernández-Somoano A, Forastiere F, Gehring U, Ghassabian A, Heude B, Jaddoe VW, Klümper C, Kogevinas M, Krämer U, Larroque B, Lertxundi A, Lertxuni N, Murcia M, Navel V, Nieuwenhuijsen M, Porta D, Ramos R, Roumeliotaki T, Slama R, Sørensen M, Stephanou EG, Sugiri D, Tardón A, Tiemeier H, Tiesler CM, Verhulst FC, Vrijkotte T, Wilhelm M, Brunekreef B, Pershagen G, Sunyer J: Air pollution during pregnancy and childhood cognitive and pychomotor development: six European birth cohorts. Epidemiology 25(5): 636-647, 2014. [pubmed]

Newson RB, van Ree R, Forsberg B, Janson C, Lötvall J, Dahlén SE, Toskala EM, Baelum J, Brożek GM, Kasper L, Kowalski ML, Howarth PH, Fokkens WJ, Bachert C, Keil T, Krämer U, Bislimovska J, Gjomarkaj M, Loureiro C, Burney PG, Jarvis D: Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA2LEN survey. Allergy 69(5): 643-651, 2014. [pubmed]

Obaseki D, Potts J, Joos G, Baelum J, Haahtela T, Ahlström M, Matricardi P, Kramer U, Gjomarkaj M, Fokkens W, Makowska J, Todo-Bom A, Toren K, Janson C, Dahlen SE, Forsberg B, Jarvis D, Howarth P, Brozek G, Minov J, Bachert C, Burney P; The GALEN network of excellence: The relation of airway obstruction to asthma, chronic rhinosinusitis and age: results from a population survey of adults. Allergy 69(9): 1205-1214, 2014. [pubmed]

de Hoogh K, Korek M, Vienneau D, Keuken M, Kukkonen J, Nieuwenhuijsen MJ, Badaloni C, Beelen R, Bolignano A, Cesaroni G, Pradas MC, Cyrys J, Douros J, Eeftens M, Forastiere F, Forsberg B, Fuks K, Gehring U, Gryparis A, Gulliver J, Hansell AL, Hoffmann B, Johansson C, Jonkers S, Kangas L, Katsouyanni K, Künzli N, Lanki T, Memmesheimer M, Moussiopoulos N, Modig L, Pershagen G, Probst-Hensch N, Schindler C, Schikowski T, Sugiri D, Teixidó O, Tsai MY, Yli-Tuomi T, Brunekreef B, Hoek G, Bellander T: Comparing land use regression and dispersion modelling to assess residential exposure to ambient air pollution for epidemiological studies. Environ Int 73C: 382-392, 2014. [pubmed]

Eze IC, Schaffner E, Fischer E, Schikowski T, Adam M, Imboden M, Tsai M, Carballo D, von Eckardstein A, Künzli N, Schindler C, Probst-Hensch N: Long-term air pollution exposure and diabetes in a population-based Swiss cohort. Environ Int 70C: 95-105, 2014. [pubmed] (open access)

Wang M, Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen ZJ, Hoffmann B, Fischer P, Houthuijs D, Nieuwenhuijsen M, Weinmayr G, Vineis P, Xun WW, Dimakopoulou K, Samoli E, Laatikainen T, Lanki T, Turunen AW, Oftedal B, Schwarze P, Aamodt G, Penell J, De Faire U, Korek M, Leander K, Pershagen G, Pedersen NL, Ostenson CG, Fratiglioni L, Eriksen KT, Sørensen M, Tjønneland A, Bueno-de-Mesquita B, Eeftens M, Bots ML, Meliefste K, Krämer U, Heinrich J, Sugiri D, Key T, de Hoogh K, Wolf K, Peters A, Cyrys J, Jaensch A, Concin H, Nagel G, Tsai MY, Phuleria H, Ineichen A, Künzli N, Probst-Hensch N, Schaffner E, Vilier A, Clavel-Chapelon F, Declerq C, Ricceri F, Sacerdote C, Marcon A, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Sokhi RS, Brunekreef B, Katsouyanni K, Hoek G: Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ Int 66C: 97-106, 2014. [pubmed]

Schuler D, Sansone R, Freudenberger T, Rodriguez-Mateos A, Weber G, Momma T, Goy C, Altschmied J, Haendeler J, Fischer JW, Kelm M, Heiss C: Measurement of endothelium-dependent vasodilation in mice. Arterioscler Thromb Vasc Biol 34(12): 2651-2657, 2014. [pubmed]

Kohlboeck G, Romanos M, Tiesler C, Koletzko S, Kratzsch J, Thiery J, Bauer CP, von Berg A, Berdel D, Hoffmann B, Schaaf B, Lehmann I, Herbarth O, Heinrich J; GINI-plus and LISA-plus study groups. Peer problems are associated with elevated serum leptin levels in children. Psychol Med 44(2): 255-265, 2014. [pubmed]

German National Cohort (GNC) Consortium (Linseisen J, … Hoffmann B, et al.): The German National Cohort: aims, study design and organization. Eur J Epidemiol 29(5): 371-382, 2014. [pubmed] (open access)

Gassmann K, Schreiber T, Dingemans MML, Krause G, Roderigo C, Giersiefer S, Schuwald J, Moors M, Unfried K, Bergman A, Westerink RHS, Rose CR, Fritsche E: BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms. Arch Toxicol 88: 1537-1548, 2014. [pubmed]

Mangerich A, Esser C: Chemical warfare in the First World War: reflections 100 years later. Arch Toxicol 88(11): 1909-1911, 2014. [pubmed]

van Berlo D*, Wilhelmi V*, Boots AW, Hullmann M, Kuhlbusch TAJ, Bast A, Schins RPF, Albrecht C: Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung. Arch Toxicol 88(9): 1725-1737, 2014. (* equal contribution) [pubmed]

Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K: Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts. Aging (Albany NY). 6(10): 856-878, 2014. [pubmed]

Müller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H: Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency. Endocrinology 155(1): 315-325, 2014. [pubmed]

Vogel CFA, Kahn EM, Leung P, Gershwin ME, Chang WLW, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS: Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for NF-κB. Journal of Biological Chemistry 289(3): 1866-1875, 2014. [pubmed] (open access)

Globisch T, Steiner N, Fülle L, Lukacs-Kornek V, Degrandi D, Dresing P, Alferink J, Lang R, Pfeffer K, Beyer M, Weighardt H, Kurts C, Ulas T, Schultze JL, Förster I: Cytokine-dependent regulation of denditic cell differentiation in the splenic microenvironment. Eur J Immunol 44(2): 500-510, 2014. [pubmed]

Clift MJD, Endes C, Vanhecke D, Wick P, Gehr P, Schins RPF, Petri-Fink A, Rothen-Rutishauser B: A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes. Toxicological Sciences 137(1): 55-64, 2014. [pubmed]

Newson R, Jones M, Forsberg B, Janson C, Bossios A, Dahlen SE, Toskala E, Al-Kalemji A, Kowalski M, Rymarczyk B, Salagean E, van Drunen C, Bachert C, Wehrend T, Krämer U, Mota-Pinto A, Burney P, Leynaert B, Jarvis D: The association of asthma, nasal allergies and positive skin prick tests with obesity, leptin and adiponectin. Clin Exp Allergy 44(2): 250-260, 2014. [pubmed]

Kersseboom S, Horn S, Visser WE, Chen J, Friesema ECH, Vaurs-Barrière C, Peeters RP, Heuer H, Visser TJ: In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency. Mol Endocrinol 28: 1961-1970, 2014. [pubmed]

Grether-Beck S, Felsner I, Koehler T, Farwick M, Lersch P, Rawlings A, Krutmann J: Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis. Exp Dermatol 23: 853-864, 2014. [pubmed]

Teichert T, Vossoughi M, Vierkötter A, Sugiri D, Schikowski T, Hoffmann B, Schulte T, Roden M, Raulf-Heimsoth M, Luckhaus C, Krämer U, Herder C: Investigating the spill-over hypothesis: Analysis of the association between local inflammatory markers in sputum and systemic inflammatory mediators in plasma. Environ Res 134: 24-32, 2014. [pubmed]

Brüske I, Standl M, Weidinger S, Klümper C, Hoffmann B, Schaaf B, Herbarth O, Lehmann I, von Berg A, Berdel D, Bauer CP, Koletzko S, Heinrich J, Lisaplus Study Groups FT: Epidemiology of urticaria in infants and young children in Germany - Results from the German LISAplus and GINIplus Birth Cohort Studies. Pediatr Allergy Immunol 25: 36-42, 2014. [pubmed]

Pei Z, Heinrich J, Fuertes E, Flexeder C, Hoffmann B, Lehmann I, Schaaf B, von Berg A, Koletzko S; Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics (LISAplus) Study Group: Cesarean delivery and risk of childhood obesity. J Pediatr 164(5): 1068-1073, 2014. [pubmed]

Czypiorski P*, Altschmied J*, Rabanter LL, Goy C, Jakob S, Haendeler J: Outfielders playing in the infield: functions of aging-associated "nuclear" proteins in the mitochondria. Curr Mol Med 14(10): 1247-1251, 2014. (* equal contribution) [pubmed]

Kohlboeck G, Romanos M, Teuner CM, Holle R, Tiesler CM, Hoffmann B, Schaaf B, Lehmann I, Herbarth O, Koletzko S, Bauer CP, von Berg A, Berdel D, Heinrich J: Healthcare use and costs associated with children's behavior problems. Eur Child Adolesc Psychiatry 23(8): 701-714, 2014. [pubmed]

Kahl S, Straßburger K, Nowotny B, Livingstone R, Klüppelholz B, Keßel K, Hwang JH, Giani G, Hoffmann B, Pacini G, Gastaldelli A, Roden M: Comparison of liver fat indices for the diagnosis of hepatic steatosis and insulin resistance. Plos one 9(4): e94059, 2014. [pubmed] (open access)

Tamayo T, Rathmann W, Krämer U, Sugiri D, Grabert M, Holl RW: Is particle pollution in outdoor air associated with metabolic control in type 2 diabetes? Plos one 9(3): e91639, 2014. [pubmed] (open access)

Autengruber A, Sydlik U, Kroker M, Hornstein T, Ale-Agha N, Stöckmann D, Bilstein A, Albrecht C, Paunel-Görgülü A, Suschek CV, Krutmann J, Unfried K: Signalling-dependent adverse health effects of carbon nanoparticles are prevented by the compatible solute beta mannosylglycerate (firoin) in vitro and in vivo. Plos one 9(11): e111485, 2014. [pubmed]

Goy C, Czypiorski P, Altschmied J, Jakob S, Rabanter L, Brewer AC, Ale-Agha N, Dyballa-Rukes N, Shah AM, Haendeler J: The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4. Exp Gerontol 56: 45-52, 2014. [pubmed]

Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Körer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F: Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Exp Gerontol 56: 59-68, 2014. [pubmed]

Maglioni S, Schiavi A, Runci A, Shaik A, Ventura N: Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis. Exp Gerontol 56: 89-98, 2014. [pubmed]

Schneider R, Linka RM, Reinke H: HSP90 affects the stability of BMAL1 and circadian gene expression. J Biol Rhythms 29(2): 87-96, 2014. [pubmed]

Fuertes E, Markevych I, von Berg A, Bauer CP, Berdel D, Koletzko S, Sugiri D, Heinrich J: Greenness and allergies: evidence of differential associations in two areas in Germany. J Epidemiol Community Health 68(8): 787-790, 2014. [pubmed] (open access)

Fuertes E, MacIntyre E, Agius R, Beelen R, Brunekreef B, Bucci S, Cesaroni G, Cirach M, Cyrys J, Forastiere F, Gehring U, Gruzieva O, Hoffmann B, Jedynska A, Keuken M, Klümper C, Kooter I, Korek M, Krämer U, Mölter A, Nieuwenhuijsen M, Pershagen G, Porta D, Postma DS, Simpson A, Smit HA, Sugiri D, Sunyer J, Wang M, Heinrich J: Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: Results from the ESCAPE and TRANSPHORM projects. Int J Hyg Environ Health 217(8): 819-829, 2014. [pubmed]

Liu C, Fuertes E, Tiesler CM, Birk M, Babisch W, Bauer CP, Koletzko S, von Berg A, Hoffmann B, Heinrich J; GINIplus; LISAplus; Study Groups: The associations between traffic-related air pollution and noise with blood pressure in children: Results from the GINIplus and LISAplus studies. Int J Hyg Environ Health 217(4-5): 499-505, 2014. [pubmed]

Liu C, Flexeder C, Fuertes E, Cyrys J, Bauer CP, Koletzko S, Hoffmann B, von Berg A, Heinrich J; for the GINIplus and LISAplus Study Groups: Effects of air pollution on exhaled nitric oxide in children: Results from the GINIplus and LISAplus studies. Int J Hyg Environ Health 217(4-5): 483-491, 2014. [pubmed]

Kuhlbusch, TAJ, Quincey P, Fuller GW, Kelly F, Mudway I, Viana M, Querol X, Alastuey A, Katsouyanni K, Weijers E, Borowiak A, Gehrig R, Hueglin C, Bruckmann P, Favez O, Sciare J, Hoffmann B, Yttri KE, Torseth K, Sager U, Asbach C: New Directions: The future of European urban air quality monitoring. Atmospheric Environment 87: 258-260, 2014.

Nonnemacher M, Jakobs H, Viehmann A, Vanberg I, Kessler C, Moebus S, Möhlenkamp S, Erbel R, Hoffmann B, Memmesheimer M, on behalf of the Heinz Nixdorf Recall Study Investigative Group. Spatio-temporal modelling of residential exposure to particulate matter and gaseous pollutants for the Heinz Nixdorf Recall Cohort. Atmospheric Environment 91: 15-23, 2014. (abstract)

Schmuck M, Temme T, Heinz S, Baksmeier C, Mosig A, Colomina MT, Barenys M, Fritsche E: Automatic counting and positioning of 5-bromo-2-deoxyuridine (BrdU) positive cells in cortical layers of rat brain slices. Neurotoxicology 43: 127-133, 2014. [pubmed]

Van Berlo D*, Hullmann M*, Wessels A, Scherbart AM, Cassee FR, Gerlofs-Nijland ME, Albrecht C, Schins RPF. Investigation of the effects of short-term inhalation of carbon nanoparticles on brains and lungs of C57BL/6J and p47phox-/- mice. Neurotoxicology 43: 65-72, 2014. (* equal contribution) [pubmed]

Speckmann B, Bidmon HJ, Borchardt A, Sies H, Steinbrenner H: Intestinal selenoprotein P in epithelial cells and in plasma cells. Arch Biochem Biophys 541: 30-36, 2014. [pubmed]

Flexeder C, Thiering E, Kratzsch J, Klümper C, Koletzko B, Müller MJ, Koletzko S, Heinrich J. Is a child's growth pattern early in life related to serum adipokines at the age of 10 years? Eur J Clin Nutr 68(1): 25-31, 2014. [pubmed]

Hellack B, Yang A, Cassee FR, Janssen NAH, Schins RPF, Kuhlbusch TAJ: Intrinsic hydroxyl radical generation measurements directly from sampled filters as a metric for the oxidative potential of ambient particulate matter. J Aerosol Sci 72: 47-55, 2014.

Rajalin AM, Micoogullari M, Sies H, Steinbrenner H: Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes. Biol Chem 395(6): 667–677, 2014. [pubmed]

Kälsch H, Lehmann N, Berg MH, Mahabadi AA, Mergen P, Möhlenkamp S, Bauer M, Kara K, Dragano N, Hoffmann B, Moebus S, Schmermund A, Stang A, Jöckel KH, Erbel R: Coronary artery calcification outperforms thoracic aortic calcification for the prediction of myocardial infarction and all-cause mortality: The Heinz Nixdorf Recall Study. Eur J Prev Cardiol 21(9): 1163-1170, 2014. [pubmed]

Barenys M, Boix N, Farran-Codina A, Palma-Linares I, Roser M, Curto A, Gomez-Catalan J, Ortiz P, Deza N, Llobet JM: Heavy metal and metalloids intake risk assessment in the diet of a rural population living near a gold mine in the Peruvian Andes (Cajamarca). Food Chem Toxicol 71: 254-263, 2014. [pubmed]

Batscheider A, Rzehak R, Teuner CM, Wolfenstetter SB, Leidl R, von Berg A, Berdel D, Hoffmann B, Heinrich J for the GINIplus and LISAplus study groups. Development of BMI values of German children and their healthcare costs. Econ Hum Biol 12: 56-66, 2014. [pubmed]

Macpherson L, Ahmed S, Tamblyn L, Krutmann J, Förster I, Weighardt H, Matthews J: Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. Int J Mol Sci 15(5): 7939-7957, 2014. [pubmed]

Markevych I, Thiering E, Fuertes E, Sugiri D, Berdel D, Koletzko S, von Berg A, Bauer CP, Heinrich J: A cross-sectional analysis of the effects of residential greenness on blood pressure in 10 year old children: Results from the GINIplus and LISAplus studies. BMC Public Health 14(1): 477, 2014. [pubmed] (open access)

Vossoughi M, Schikowski T, Vierkötter A, Sugiri D, Hoffmann B, Teichert T, Herder C, Schulte T, Luckhaus C, Raulf-Heimsoth M, Casjens S, Brüning T, Krämer U: Air pollution and subclinical airway inflammation in the SALIA cohort study. Immunity & Ageing 11(1): 5, 2014. (open access)

Soppa VJ, Schins RPF, Hennig F, Hellack B, Quass U, Kaminski H, Kuhlbusch TAJ, Hoffmann B, Weinmayr G: Respiratory effects of fine and ultrafine particles from indoor sources- a randomized sham-controlled exposure study of healthy volunteers. Int J Environ Res Public Health 11(7): 6871-6889, 2014. [pubmed] (open access)

Winkler V, Leitzmann M, Obi N, Ahrens W, Edinger T, Giani G, Linseisen J, Löffler M, Michels K, Nöthlings U, Schipf S, Kluttig A, Wichmann HE, Hoffmann B, Jöckel KH, Becher H: Response in individuals with and without foreign background and application to the National Cohort in Germany: which factors have an effect? Int J Public Health 59(3): 555-563, 2014. [pubmed]

Wawro N, Heinrich J, Thiering E, Kratzsch J, Schaaf B, Hoffmann B, Lehmann I, Bauer CP, Koletzko S, von Berg A, Berdel D, Linseisen J: Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies. BMC Pediatr 14(1): 286, 2014. [pubmed] (open access)

Marini A, Jaenicke T, Grether-Beck S, Le Floc'h C, Cheniti A, Piccardi N, Krutmann J: Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, ß-carotene and Lactobacillus johnsonii: Results from a randomized, placebo-controlled, double-blinded study. Photodermatol Photoimmunol Photomed 30(4): 189-194, 2014. [pubmed]

Müller J, Heuer H: Expression pattern of thyroid hormone transporters in the postnatal mouse brain. Frontiers in Endocrinology Vol. 5, Article 92, 2014. [pubmed] (open access)

Unfried K, Kroker M, Autengruber A, Gotic M, Sydlik U: The compatible solute ectoine reduces the exacerbating effects of environmental model particles on the immune response of the airways. J Allergy 2014: 708458. [pubmed] (open access)

Baumann J, Barenys M, Gassmann K, Fritsche E: Comparative human and rat "neurosphere assay" for developmental neurotoxicity testing. Curr Protoc Toxicol 59: 12.21.1-12.21.24, 2014. [pubmed]

Übersichtsarbeiten, Buchbeiträge u.a.

Schikowski T, Mills IC, Anderson HR, Cohen A, Hansell A, Kauffmann F, Krämer U, Marcon A, Perez L, Sunyer J, Probst-Hensch N, Künzli N: Ambient air pollution - a cause for COPD? Eur Respir J 43(1): 250-263, 2014. [pubmed]

Sies H: Role of metabolic H2O2 generation: Redox signalling and oxidative stress. J Biol Chem 289(13): 8735-8741, 2014. [pubmed]

Esser C: A fat story - antigen presentation by butyrophilin 3A1 to γδ T cells. Cell Mol Immunol 11(1): 5-7, 2014. [pubmed]

Alépée N, Bahinski T, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K, Zurich MG: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX 31(4): 441-477, 2014. [pubmed]

Crofton K, Fritsche E, Ylikomi T, Bal-Price A: International STakeholder NETwork (ISTNET) for Creating a Developmental Neurotoxicity Testing (DNT) Roadmap for Regulatory Purposes. ALTEX 31(2): 223-224, 2014. [pubmed]

Ale-Agha N, Dyballa-Rukes N, Jakob S, Altschmied J, Haendeler J: Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase - Potential role in senescence and aging. Exp Gerontol 56: 189-193, 2014. [pubmed]

Schiavi A, Ventura N: The interplay between mitochondria and autophagy and its role in the aging process. Exp Gerontol 56: 147-153, 2014. [pubmed]

Trifunovic A, Ventura N: Mitochondria and metabolic control of the aging process (editorial). Exp Gerontol 56: 1-2, 2014. [pubmed]

Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F: The Hallmarks of Fibroblast Ageing. Mech Ageing Dev 138: 26-44, 2014. [pubmed]

Krutmann J, Liu W, Li L, Pan X, Crawford M, Sore G, Seite S: Pollution and skin: From epidemiological and mechanistic studies to clinical implications. J Dermatol Sci 76(3): 163-168, 2014. [pubmed]

Luger T, Seité S, Humbert P, Krutmann J, Triller R, Dreno B: Recommendations for adjunctive basic skin care in patients with psoriasis. Eur J Dermatol 24(2): 194-200, 2014. [pubmed]

Grether-Beck S, Marini A, Jaenicke T, Krutmann J: Photoprotection of human skin beyond ultraviolet radiation. Photodermatol Photoimmunol Photomed 30(2-3): 167-174, 2014. [pubmed]

Krutmann J, Béhar-Cohen F, Baillet G, de Ayguavives T, Ortega Garcia P, Peña-García P, Remé C, Wolffsohn J: Towards standardization of UV eye protection: what can be learned from photodermatology? Photodermatol Photoimmunol Photomed 30(2-3): 128-136, 2014. [pubmed]

Behar-Cohen F, Baillet G, de Ayguavives T, Garcia PO, Krutmann J, Peña-García P, Reme C, Wolffsohn JS: Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear. Clin Ophthalmol 8: 87-104, 2014. [pubmed]

von Mikecz A: Pathology and function of nuclear amyloid: protein homeostasis matters. Nucleus 5(4): 311-317, 2014. [pubmed]

Birmili W, Rückerl R, Hoffmann B, Weinmayr G, Schins R, Kuhlbusch TAJ, Vogel A, Weber K, Franck U, Cyrys J, Peters A: Ultrafine aerosol particles in ambient air: Perspectives to elucidate their health effects (Ultrafeine Aerosolpartikel in der Außenluft: Perspektiven zur Aufklärung ihrer Gesundheitseffekte). Gefahrst Reinh Luft 74(11/12): 492-500, 2014. (abstract)

Arnhold F, von Mikecz A: Intranuclear amyloid – local and quantitative analysis of protein fibrillation in the cell nucleus. In: Bionanoimaging: Insights into protein misfolding and aggregation. Vladimir Uversky & Yuri Lyubchenko (Eds.), Elsevier 2014, pp. 475-483.

Boland S, Vranic S, Schins RPF, Stöger T: Current in vitro models for nanomaterial testing in pulmonary systems. In: Nanotoxicology (2nd Edition): Progress Towards Nanomedicine. Monteiro-Riviere N, Tran CL (Eds.). CRC Press 2014, pp. 291-314.

Fritsche E: Human stem/progenitor cell-based assays for neurodevelopmental toxicity testing. In: In vitro toxicology systems. Bal-Price A, Jennings P (Eds.). Humana Press 2014, pp. 351-376.

Esser C: The Aryl Hydrocarbon Receptor (AhR) as a Mediator of Adverse Immune Reactions. In: Molecular Immunotoxicology. Corsini E, Van Loveren H (Eds). Wiley Verlag 2014.

Behrendt H, Alessandrini F, Buters J, Krämer, U, Koren H, Ring J: Environmental Pollution and Allergy: Historical Aspects. In: History of Allergy. Chem Immun Allergy, Vol. 100. Bergmann KC, Ring J (Eds.). S. Karger Verlag 2014.