Publikationen 2010


Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U: Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142 (6): 943-953, 2010.

Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Förster I, Kurts C: Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell–licensed DCs. Nature Immunology 11(4): 313-320, 2010.

Manolopoulos KN, Klotz LO, Korsten P, Bornstein SR, Barthel A: Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress. Mol Psychiatry 15(11): 1046-1052, 2010.

Kamenisch Y, Fousteri M, Knoch J, von Thaler AK Fehrenbacher B, Dolle M, Kuiper R, Majora M, Schaller M, van Steeg H, Röcken M, Krutmann J* , Mullenders LH*, Berneburg M: Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med 207(2): 379-390, 2010.(* equal contribution)

Stabenow D, Frings M, Trück C, Gärtner K, Förster I, Kurts C, Tüting T, Odenthal M, Dienes HP, Cederbrand K, Protzer U, Knolle PA: Bioluminescence imaging allows measuring CD8 T cell function in the liver. Hepatology 51 (4): 1430-1437, 2010.

Stutte S, Quast T, Gerbitzki N, Savinko T, Novak N, Reifenberger J, Homey B, Kolanus W, Alenius H, Förster I: Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells. Proc Natl Acad Sci USA 107 (19): 8736-8741, 2010.

Cramer C, Link E, Horster M, Koletzko S, Bauer CP, Berdel D, von Berg A, Lehmann I, Herbarth O, Borte M, Schaaf B, Behrendt H, Chen CM, Sausenthaler S, Illig T, Wichmann H-E, Heinrich J, Krämer U, for the GINI and LISAplus study group: Elder siblings enhance the effect of filaggrin mutations on childhood eczema – results from the two birth cohort studies LISAplus and GINIplus. J Allergy Clin Immunol 125(6): 1254-1260, 2010.

Schmitt J, Apfelbacher C, Chen CM, Romanos M, Sausenthaler S, Koletzko S, Bauer CP, Hoffmann U, Krämer U, Berdel D, von Berg A, Wichmann HE, Heinrich J, German Infant Nutrition Intervention plus Study Group: Infant onset eczema in relation to mental health problems at age 10 years: Results from a prospective birth cohort study (German Infant Nutrition Intervention plus). J Allergy Clin Immunol 125(2): 404-410, 2010.

Krämer U, Herder C, Sugiri D, Strassburger K, Schikowski T, Ranft U, Rathmann W: Traffic-related air pollution and incident type 2 diabetes: Results from the SALIA cohort study. Environ Health Perspect 118(9): 1273-1279, 2010.

Rückinger S, Rzehak P, Chen CM, Sausenthaler S, Koletzko S, Bauer CP, Hoffmann U, Krämer U, Berdel D, von Berg A, Bayer O, Wichmann HE, von Kries R, Heinrich J, GINIplus Study Group: Prenatal and Postnatal Tobacco Exposure and Behavioural Problems in 10 Year Old Children: Results from the GINI-plus Prospective Birth Cohort Study. Environ Health Perspect 118(1): 150-154, 2010.

Schreiber T, Gassmann K, Götz C, Hübenthal U, Moors M, Krause G, Merk HF, Crofton KM, Nguyen NH, Scanlan TS, Abel J, Rose CR, Fritsche E: Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: Evidence for endocrine disruption. Environ Health Perspect 118(4): 572-578, 2010.

Speckmann B, Pinto A, Winter M, Förster I, Sies H, Steinbrenner H: Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS-2 induction. Free Radic Biol Med 49(5): 777-785, 2010.

van Berlo D, Wessels A, Boots A, Wilhelmi V, Scherbart A, Gerloff K, van Schooten FJ, Albrecht C, Schins R: Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles. Free Radic Biol Med  49(11): 1685-93, 2010.

Weissenberg A*, Sydlik U*, Peuschel H, Schroeder P, Schneider M, Schins RP, Abel J, Unfried K: Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles. Free Radic Biol Med 49: 597–605, 2010. (*equal contribution)

Seeger FH, Sedding D, Langheinrich A, Chen-Wichmann L, Haendeler J, Zeiher AM, Dimmeler S: Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression. Basic Res Cardiol 110: 389-397, 2010.

Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B: TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. J Immunol 184(10): 5842-5848, 2010.

Calles C, Schneider M, Macaluso F, Benesova T, Krutmann J, Schroeder P: Infrared-A radiation influences the skin fibroblast transcriptome: mechanisms and consequences. J Invest Dermatol 130(6): 1524-1536, 2010.

Vierkötter A, Schikowski T, Ranft U , Sugiri D, Matsui M, Krämer U, Krutmann J: Airborne particle exposure and extrinsic skin aging. J Invest Dermatol 130(12): 2719-2726, 2010.

Fernau NS, Fugmann D, Leyendecker M, Reimann K, Grether-Beck S, Galban S, Ale-Agha N, Krutmann J, Klotz LO: Role of HuR and p38-MAP kinase in ultraviolet B-induced posttranscriptional regulation of cyclooxygenase-2 expression in the human keratinocyte cell line HaCaT. J Biol Chem 285(6): 3896-3904, 2010.

Chmill S, Kadow S, Winter M, Weighardt H, Esser C: 2,3,7,8-Tetrachlorodibenzo-P-dioxin impairs stable establishment of oral tolerance in mice. Toxicol Sci 118(1): 98-107, 2010.

Wessels A, Birmili W, Albrecht C, Hellack B, Jermann E, Wick G, Harrison RM, Schins RPF: Oxidant generation and toxicity of size-fractionated ambient particles in A549 human lung epithelial cells. Environ Sci Technol 44 (9): 3539-3545, 2010.

Luecke S, Backlund M, Jux B, Esser C, Krutmann J, Rannug A: The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis.  Pigment Cell & Melanoma Research 23(6): 828-833, 2010.

Moors M, Vudattu NK, Abel J, Krämer U, Rane L, Ulfig N, Ceccatelli S, Seyfert-Margolies V, Fritsche E, Maeurer MJ: Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells. Genes Immun 11(1): 11-20, 2010.

Krämer U, Oppermann H, Ranft U, Schäfer T, Ring J, Behrendt H: Differences in allergy trends between East and West Germany and possible explanations. Clinical Experimental Allergy 40(2): 289-298, 2010.

Schnabel E, Sausenthaler S, Schaaf B, Schäfer T, Lehmann I, Behrendt H, Herbarth O, Borte M, Krämer U, von Berg A, Wichmann HE, Heinrich J; for the LISA Study Group: Prospective association between food sensitization and food allergy: results of the LISA birth cohort study. Clin Exp Allergy 40(3): 450-457, 2010.

von Berg A, Krämer U, Link E, Bollrath C, Heinrich J, Brockow I, Koletzko S, Grübl A, Filipiak-Pittroff B, Wichmann HE, Bauer CP, Reinhardt D, Berdel D, GINIplus Study Group: Impact of early feeding on childhood eczema: Development after nutritional intervention compared with the natural course: The GINIplus study up to the age of six years. Clin Exp Allergy 40(4): 627-636, 2010.

Ghiazza M, Scherbart AM, Fenoglio I, Grendene F, Turci F, Martra G, Albrecht C, Schins RP, Fubini B: Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. Chem Res Toxicol 24(1): 99-110, 2011.

Mann E, Ranft U, Eberwein G, Gladtke D, Sugiri D, Behrendt H, Ring J, Schäfer T, Begerow J, Wittsiepe J, Krämer U, Wilhelm M: Does airborne nickel exposure induce nickel senistization? Contact Dermatitis 62(6): 355-362, 2010.

Demircigil Cakmak G, Coskun E, Vidinli N, Erbas Y, Yilmaz M, Cimrin A, Schins RPF, Borm PJA, Burgaz S: Increased micronucleus frequencies in surrogate and target cells from workers exposed to crystalline silica containing dust. Mutagenesis 25: 163-169, 2010.

Büchner N, Zschauer TC, Lukosz M, Altschmied J, Haendeler J: Downregulation of mitochondrial Telomerase Reverse Transcriptase induced by H2O2 is Src kinase dependent. Exp Gerontol 45(7-8): 558-562, 2010.

Haarmann-Stemmann T, Sendker J, Götz C, Krug N, Bothe H, Fritsche E, Proksch P, Abel J: Regulation of human dioxin receptor function by different beta-carboline alkaloids. Archives of Toxicology 84 (8): 619-629, 2010.

van Berlo D, Albrecht C,  Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ, Krutmann J, Schins RPF: Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch Toxicol 84(7): 553-562, 2010.

Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R: Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology 131(3): 395-404, 2010.

Sausenthaler S, Koletzko S, Koletzko B, Reinhardt D, Krämer U, von Berg A, Berdel D, Bauer CP, Grübl A, Wichmann HE, Heinrich J; for the GINIplus study group: Effect of hydrolysed formula feeding on taste preferences at 10 years. Data from the German Infant Nutritional Intervention Program Plus Study. Clin Nutr 29(3): 304-306, 2010.

Nicolescu R, Petcu C, Cordeanu A, Fabritius K, Schlumpf M, Krebs R, Krämer U, Winneke G: Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: Performance and questionnaire data. Environ Res 110(5): 476-483, 2010.

Schikowski T, Ranft U, Sugiri D, Vierkötter A, Brüning T, Harth V, Krämer U: Decline in air pollution and change in prevalence in respiratory symptoms and chronic obstructive pulmonary disease in elderly women. Respir Res 11(1): 113, 2010.

Bartholome A, Kampkötter A, Tanner S, Sies H, Klotz LO: Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture. Arch Biochem Biophys 501(1): 58-64, 2010.

Bothe H, Götz C, Stobbe-Maicherski N, Fritsche E, Abel J, Haarmann-Stemmann T: Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. Archives of Biochemistry and Biophysics 498(2): 111-118, 2010.

Klaus V, Hartmann T, Gambini J, Graf P, Stahl W, Hartwig A, Klotz LO: 1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes. Arch Biochem Biophys 496(2): 93-100, 2010.

Krefis AC, Schwarz NG, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie Y, Ranft U, May J: Principal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana. Malaria J 9(1): 201, 2010.

Smolders R, Alimonti A, Cerna M, Den Hond E, Kristiansen J, Palkovicova L, Ranft U, Seldén AI, Telišman S, Schoeters G: Availability and comparability of human biomonitoring data across Europe: A case-study on blood-lead levels. Sci Total Environ 408(6): 1437-1445, 2010.

Orru H, Kimmel V, Kikas Ü, Soon A, Künzli N, Schins RPF, Borm PJA, Forsberg B: Elemental Composition and Oxidative Properties of PM2.5 in Estonia in Relation of Origin of Air Masses - results from ERCHS II in Tartu. Sci Tot Environ 408(7): 1515-1522, 2010.

Assfalg V, Hüser N, Reim D, Kaiser-Moore S, Rossmann-Bloeck T, Weighardt H, Novotny AR, Stangl MJ, Holzmann B, Emmanuel KL: Combined immunosuppressive and antibiotic therapyimproves bacterial clearance and survival of polymicrobial septic peritonitis. Shock 33(2): 155-161, 2010.

MacIntyre EA, Chen CM, Herbarth O, Borte M, Schaaf B, Krämer U, von Berg A, Wichmann HE, Heinrich J, LISA Study Group: Early-life otitis media and incident atopic disease at school age in a birth cohort. Pediatr Infect Dis J 29(12): e96-e99, 2010.

Ale-Agha N, Albrecht C, Klotz LO: Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to carbon or silica-based nanoparticles. Biol Chem 391(11): 1333-1339, 2010.

Peuschel H, Sydlik U, Haendeler J, Büchner N, Stökmann D, Kroker M, Wirth R, Brock W, Unfried K: c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategy. Biol Chem 391(11): 1327-1332, 2010.

Apfelbacher C, Ollert M, Ring J, Behrendt H, Krämer U: Contact to cat or dog, allergies and parental education. Pediatr Allergy Immunol 21(2 Pt 1): 284-291, 2010.

Herberth G, Daegelmann C, Röder S, Behrendt H, Krämer U, Borte M, Heinrich J, Herbarth O, Lehmann I; for the LISAplus study group: IL-17E but not IL-17A is associated with allergic sensitization: results from the LISA study. Pediatr Allergy Immunol 21(7): 1086-90, 2010.

Schroeder P, Calles C, Benesova T, Macaluso F, Krutmann J: Photoprotection beyond UV – effective sun protection has to include protection against infrared A radiation induced skin damage. Skin Physiology and Pharmacology 23(1): 15-17, 2010.

Rzehak P, Scherag A, Grallert H, Sausenthaler S, Koletzko S, Bauer CP, Schaaf B, von Berg A, Berdel D, Borte M, Herbarth O, Krämer U, Illig T, Wichmann HE, Hebebrand J, Heinrich J, Gini And Lisa Study Group: Associations between BMI with the FTO gene are age dependent: Results from the GINI and LISA Birth Cohort Studies up to age 6 years. Obesity Facts 3(3): 173-180, 2010.

Germing A, Gotzmann M, Rauße R, Brodherr T, Holt S, Lindstaedt M, Dietrich J, Ranft U, Krämer U, Mügge A: Normal values for longitudinal function of the right ventricle in healthy women >70 years of age. Eur J Echocardiogr 11 (8): 725-728, 2010.

Chen CM, Sausenthaler S, Bischof W, Herbarth O, Borte M, Behrendt H, Krämer U, Williams HC, Wichmann HE, Heinrich J; the LISA Study Group: Perinatal exposure to endotoxin and the development of eczema during the first 6 years of life. Clin Exp Dermatol 35(3): 238-244, 2010.

Henry J, Casjens S, Schikowski T, Stachon A, Germing A, Ranft U, Lehnert M, Harth V, Krämer U, Brüning T, Pesch B:  Prohepcidin, B-type natriuretic peptide and iron statusin a cohort of elderly women from the Rhine-Ruhr area. Acta Haematol 124(3): 129-133, 2010.

Gerlofs-Nijland M, van Berlo D, Cassee FR, Schins RPF, Wang K, Campbell A: Effects of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol 7(1): 12, 2010.

van Berlo D, Knaapen AM, van Schooten FJ, Schins RP, Albrecht C: NF-kappaB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells. Part Fibre Toxicol 7 (1): 13, 2010.


Übersichtsarbeiten, Buchbeiträge

Abel J, Haarmann-Stemmann T: An introduction to the molecular basics of Arylhydrocarbon Receptor biology. Biological Chemistry 391(11):1235-48, 2010.

Breier JM, Gassmann K, Kayser R, Stegeman H, De Groot D, Fritsche E, Shafer TJ: Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: State of the science. Neurotoxicol Teratol 32(1): 4-15, 2010.

Buechner N, Altschmied J, Jakob S, Saretzki G, Haendeler J: Well-known signalling proteins exert new functions in the nucleus and mitochondria. Antioxid Redox Signal 13(4): 551-558, 2010.

Donaldson K, Poland C, Schins RPF: Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies. Nanotoxicology 4: 414-420, 2010.

Entschladen F, Altschmied J, Baumgrass R, Behrmann I, Giehl K, Hermanns H, Huber O, Kieser A, Klotz LO, Kubatzky KF, Hass R, Janssen O, Friedrich K: Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology. Cell Commun Signal 8: 2, 2010.

Esser C, Krutmann J: UV-Strahlung und Pigmentierung: Arylhydrocarbonrezeptor - "a new kid on the block". Der Hautarzt 61(7): 561-566, 2010.

Grether-Beck S, Krutmann J: Fettgewebe – Zelluläre und molekulare Grundlagen. Der Hauarzt 61: 838-846, 2010.

Humbert P, Robin S, Binda D, Krutmann J: Beauty from inside: Nutrition-based strategies in cosmetic dermatology. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 189-196.

Krutmann J: Pathomechanisms of photoaged skin. In: Textbook of aging skin. Farage MA, Miller KW, Maibach HI (eds.). Springer 2010, pp. 101-108.

Krutmann J: Skin Aging. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 15-24.

Krutmann J, Berking C: Pigmentstörungen. Der Hautarzt 61: 553, 2010.

Krutmann J, Lademann J, Merk HF: Main highlights of International Dermatotoxicology Symposium, Netherlands-Vaals. Skin Pharmacol Physiol 23(1): 5, 2010.

Krutmann J, Steinert M: Fettgewebe in Dermatologie und Ästhetik. Der Hautarzt 61: 837, 2010.

Krutmann J, Welzel J: Innovative physikalische Verfahren in der Dermatologie. Der Hautarzt 61(5): 386, 2010.

Lukosz M, Jakob S, Buechner N, Zschauer TC, Altschmied J, Haendeler J: Nuclear redox signalling. Antioxid Redox Signal 12(6): 713-742, 2010.

Luecke S, Backlund M, Jux B, Esser C, Krutmann J,  Rannug A: The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis. Pigment Cell & Melanoma Research 23(6): 828-833, 2010.

Montastier Ch, Mac-Mary S, Humbert P, Krutmann J: How to prove safety and efficacy in nutrition-based interventional studies for human skin. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 181-188.

Schroeder P, Krutmann J: What is needed for a sunscreen to provide complete protection. Skin Therapy Lett 15(4): 4-5, 2010.

Schröder P, Krutmann J: Infrared-A induced skin aging. In: Textbook of aging skin. Farage MA, Miller KW, Maibach HI (eds.). Springer 2010, pp. 421-426.

Vierkötter A: Einfluss von Partikeln aus dem Straßenverkehr auf die extrinsische Hautalterung. Der Hautarzt 61: 538-539, 2010.