Stellenangebote

Bitte richten Sie Ihre Initiativbewerbung inkl. Anschreiben, Lebenslauf und Zeugnisse an: Bewerbung@IUF-Duesseldorf.de

Das IUF setzt sich für eine familien- und lebensphasenbewusste Personalpolitik ein und hat dafür 2017 erneut das Zertifikat zum „audit berufundfamilie“ erhalten. Weitere Informationen dazu erhalten Sie unter dem Punkt Gleichstellung.

Unsere Datenschutzerklärung zu Bewerbungen finden Sie hier.

Environmental Epidemiologist position (f/m/d) (PhD-Student/Post-doc position)

At the IUF, several research groups are working on how environmental factors (ultraviolet radiation, air pollution, food chemicals) affect the physiology and pathophysiology of the different organs. The working group “Environmental epidemiology of lung, brain and skin aging” focuses on epidemiological aspects of air pollution-induced aging / chronic diseases of the lung, the brain and the skin. We are particularly interested in the complex interplay between these organs and in gene-environment interaction. Our studies are of global relevance and conducted not only in Germany, but also in other European as well as Asian countries.

The working group “Environmental epidemiology of lung, brain and skin aging” at the IUF - Leibniz Research Institute for Environmental Medicine in Düsseldorf is offering a Environmental Epidemiologist position (f/m/d) (PhD-Student/Post-doc position).

YOUR TASK

The main duties will be the performance of statistical analysis of health and environmental data using existing longitudinal cohort data as well as the presentation of these results at scientific conferences and meetings. The writing of research papers and grant applications is expected. 

EDUCATION AND EXPERIENCE

  • Environmental epidemiology, biostatistics, medicine, public health, or equivalent;
  • Experience in environmental epidemiological research and in-depth understanding of statistical modeling;
  • Profound hands-on experience in epidemiological techniques as well as substantial experience in working with statistical software (SAS or R);
  • Demonstrated proficiency in Microsoft Office, including Word, Excel, and PowerPoint;
  • Strong verbal and written communication skills are required (English);


DESIRED KEY COMPETENCIES

  • Positive can-do attitude, responsible and responsive, and maintain a high degree of ethical standard and trustworthiness;
  • Self-motivated, highly organized, meticulous hands-on habits, keen to accuracy, and attention to detail;
  • Strong quantitative and analytical skills, able to reach rational conclusions through complex processing of information;
  • Energized by accomplishments and excellence in the workplace. Competent of high performance in independent work and coordinated efforts in implementing group projects;
  • A strong interest in epidemiological research in general and environmental epidemiology in particular;
  • Evaluate results, analyze and interpret data to prepare project updates, meeting presentations and research reports for documentation and publication;


The position is limited for 2 years with the option of a permanent position. The weekly working time totals 39 hours and 50 minutes. Remuneration is given in accordance with the provisions of the collective agreement for the employees of the states (TV-L). Salary will be according to TV-L (E13).

Please address your application (incl. letter of motivation, CV, references, qualification certificates), preferably electronically until 1st November 2019, to:

Dr. Tamara Schikowski
IUF – Leibniz-Institut für umweltmedizinische Forschung
c/o Personalstelle
Auf’m Hennekamp 50
40225 Düsseldorf
Bewerbung@IUF-Duesseldorf.de

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Cell Biologist (f/m/d) (Post-doc position)

The core unit model development is offering a position for a Cell Biologist (f/m/d) (Post-doc position). The position is to be filled at IUF as of January 1st, 2020.

The project is focused on the potential risk of environmental toxicants including particles, chemicals and radiation)


1.) Generation and validation of human pluripotent stem cells (hPSCs) from human somatic cells including those coming from patients carrying mutations;
2.) Development and validation of 3D culture systems including organoids from human induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs);
3.) Generation of genetically engineered human cells and organoids by using CRISPR/Cas9 system of newly identified key regulators;

 

The project aims to the understanding of the underlying mechanisms and their genetic susceptibility involved in the development of pulmonary and brain disease associated with particle exposure. The candidate will work on improving various aspects of existing techniques as well as developing novel models for the investigation of lung pathogenesis after particle exposure and generation of genetically modified human lung cells and organoids.

Qualifications

We seek a highly motivated candidate (f/m) with a solid background in cell biology. Expertise in standard molecular biology techniques, cell culture and ex-vivo models is critical. Previous work with lung models is a plus. The candidate is required to have strong skills in English and German and proven abilities to publish at a high international level with at least one first author publication. Motivation to work independently and be responsible for the daily management of his/her research project in coordination with other members of the group is expected. The candidate will also be actively involved in the training and co-supervision of other group members and students.

ROLE RESPONSIBILITIES


  • The individual should apply their significant expertise in cell biology, cell culture and organoids, molecular biology based techniques, along with their understanding such as plasmid cloning, gene editing, AAV vector production, electroporation, qPCR, RT-PCR, nucleic acid extraction and cloning, gel electrophoresis, macromolecule blotting and probing and mouse handling is highly desirable.
  • Participate in the development and qualification of assays. Independently analyze data and provide conclusions. Critically evaluate own and others results and offer insights based on process and product understanding to help solve problems.
  • Contribute to patents, regulatory documents or manuscript as required.
  • Read scientific and technical literature in order to bring new and improved procedures to the laboratory, and to broaden understanding of disciplines outside area of training. Utilizes all appropriate experimental design methods needed for work in area of specialization. Conduct literature searches and apply knowledge to the approaches taken.
  • Participate in scientific discussion with colleagues through informal and formal scientific seminars and meetings.


EDUCATION AND EXPERIENCE


  • Ph.D. in Molecular Biology, Biology, Physiology, Biochemistry, or related field.
  • Minimum 3 years of experience with cell culture, iPSC cells, ex-vivo models and organoids.
  • Understanding of brain and lung physiology, cell types and co-culture systems is highly appreciated.
  • Demonstrated competency in immunohistochemistry, western blotting and DNA cloning.
  • Demonstrated proficiency in Microsoft Office, including Word, Excel, and PowerPoint.
  • Strong verbal and written communication skills are required (English and German).


DESIRED KEY COMPETENCIES


  • Self-motivated, highly organized, meticulous hands-on habits, keen to accuracy, and attention to detail.
  • Positive can-do attitude, responsible and responsive, and maintain a high degree of ethical standard and trustworthiness.
  • Strong quantitative and analytical skills, able to reach rational conclusions through complex processing of information.
  • Energized by accomplishments and excellence in the workplace. Competent of high performance in independent work and coordinated efforts in implementing group projects.
  • Maintain timely documentation of laboratory work and keep well organized records.
  • Evaluate results, analyze and interpret data to prepare projects updates, meeting presentations and research reports for documentation and publication.

 

The position is limited for to 2 years with the option of a permanent position. The weekly working time totals 39 hours and 50 minutes. Remuneration is given in accordance with the provisions of the collective agreement for the employees of the states (TV-L). Salary will be according to TV-L (E13).

Please address your application (incl. letter of motivation, CV, references, qualification certificates), preferably electronically, to:

Dr. Andrea Rossi
IUF – Leibniz-Institut für umweltmedizinische Forschung
c/o Personalstelle
Auf’m Hennekamp 50
40225 Düsseldorf
Bewerbung@IUF-Duesseldorf.de

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Student (f/m/d) for Master Thesis

The team of "UV-induced skin carcinogenesis and skin aging" lead by Prof. Petra Boukamp is looking for a student (f/m/d) for Master Thesis  in the field of organotypic models and experimental sunlight.

Thesis topic:
Studies of single solar irradiation response in a human skin equivalent.

Our group is particularly interested in understanding the underlying biological mechanisms, which give rise to skin cancer. We use long-term skin equivalents (3D in-vitro models) that have been developed in our group to address questions related to the overall effects of sun exposure in models that represent not only normal adult skin, but also aged skin and different tumorigenic states.

Background to the topic:
Even though the influence of UV irradiation on our skin has been studied for many years, we still are lacking information regarding the biological effects of sun exposure as a whole. Until now most of research has been concentrating on the influence of UV. More recently we have also been able to add more knowledge by including infrared light and visual light (IRA, VIS). While this research was conducted either with single wavelength doses or sequential irradiation, sun doesn’t include a segmental or sequential form of irradiation, but a simultaneous exposure to UV, VIS and IRA. This is why our German consortia, KAUVIR (combination instead of addition: UV to IR radiation in skin cancer and skin aging), is studying the effects of sun exposure by using a state of the art lamp that allows simultaneous irradiations with spectra similar to the sun. These studies are essential in order to get a better understanding of the “damaging” effects of “sun light” and in consequence more relevant risk estimation and prevention.

The project:
In this master thesis you will be studying the immediate as well as the long-lasting effects of single UV and experimental sunlight exposure on a 3-D model of human skin based on normal human keratinocytes or HaCaT cells. Endpoints that will be addressed are proliferation, differentiation, tissue damage, and molecular deregulation.

Your background:
We are looking for a student (f/m/d) with a background in biology, toxicology or related field of study.

You will bring:
A practical Bachelor thesis. A great knowledge in English both spoken and written as you will be working in an international atmosphere. True interest in biological systems and bioengineering, which shows in the form of enthusiasm and high motivation. Furthermore our daily cell culture work and models require that you are meticulous in practical work and well organized both inside and outside the lab. It would be desirable if you have worked in a cell culture environment and have performed regular protein and molecular biology analysis (ELISA, PCR, western blot) before.

What we can offer you:
We are a friendly and collaborative team that offers you the chance to develop your skills in the fields of skin biology, skin cancer and bioengineering.

When can you start:
From Feb-March 2020, we are flexible.

Please address your application (a short cover letter and your CV), preferably electronically, to:
Prof. Petra Boukamp, p.boukamp@dkfz-heidelberg.de and Dr. Elizabeth Pavez Loriè, elizabeth.pavezlorie@iuf-duesseldorf.de

IUF – Leibniz-Institut für umweltmedizinische Forschung
Auf’m Hennekamp 50
40225 Düsseldorf

We will contact you to arrange a meeting after the application deadline 15th of November 2019.

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Studentische Hilfskraft (m/w/d)

Im Rahmen einer Studie suchen wir zum nächstmöglichen Termin eine studentische Hilfskraft (m/w/d).

Die NAKO-Gesundheitsstudie ist eine deutschlandweite bevölkerungsbasierte Langzeitbeobachtungsstudie. In 18 regionalen Studienzentren werden dafür 200.000 Teilnehmer aus der Allgemeinbevölkerung untersucht. Nähere Informationen finden Sie auf www.nako.de. Das Studienzentrum Düsseldorf wird vom Deutschen Diabetes Zentrum (DDZ) und dem IUF - Leibniz-Institut für umweltmedizinische Forschung betrieben.

Ihre Aufgaben:

  • Eingabe von Studiendaten
  • Unterstützung bei  allgemeinen administrativen Tätigkeiten
  • Vorbereitung von Dokumentationsbögen
  • Unterstützung bei der Versandlogistik
  • Hilfe bei Laboranalysen


Wir suchen freundliche und teamfähige Mitarbeiter/innen mit guten Deutsch- und EDV-Kenntnissen. Eine sorgfältige und exakte Arbeitsweise sowie ein sicherer Umgang mit Microsoft Office setzen wir voraus. Der Beschäftigungsumfang sollte möglichst 12 Wochenstunden betragen.

Werden Sie Teil unseres Teams und richten Sie Ihre Bewerbung bitte mit aussagefähigen Unterlagen per E-Mail an: Bewerbung@IUF-Duesseldorf.de (Betreff: „NAKO“)

Per Post eingereichte Bewerbungsunterlagen werden nicht zurückgesandt. Unterlagen nicht berücksichtigter Bewerber/innen werden nach Abschluss des Verfahrens ordnungsgemäß vernichtet.

IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH
Dr. Tamara Schikowski
Auf‘m Hennekamp 50
40225 Düsseldorf

Master student (f/m/d)

The IUF-LIMES liaison group “innate immunity and extrinsic skin aging” offers a position for a Master student (f/m/d).

The position is suitable for a master student in the field of life sciences (biology, toxicology, molecular biomedicine, biochemistry, or similar) who aims to prepare a master’s thesis on immunology of the skin.

You will work on a DFG-funded project dealing with the impact of UV irradiation on the immune response in non-infectious inflammatory skin disorders. Specifically, we are interested in the functions of the transcription factor HIF-1a within the epidermis in a context of allergic skin disease.

Tasks include conventional PCR, primary cell isolation and culture, flow cytometry, histology, qPCR, Western blot, ELISA and related skills. Experience in any of these methods and their analysis will be a benefit. You are curious for doing basic research and are able to work as a responsible team member.

We offer a friendly and supportive working environment in close collaboration with other research groups within the interdisciplinary infrastructure of the IUF.

Please address your application (as one single pdf file) and any questions you may have, preferably via E-mail, to Sonja.Fassbender@IUF-Duesseldorf.de:

Dr. rer. nat. Sonja Faßbender
IUF – Leibniz-Institut für umweltmedizinische Forschung
Auf’m Hennekamp 50
40225 Düsseldorf

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Master Thesis position

The research group of Prof. Dr. Ellen Fritsche offers a Master Thesis position. Topic: 3D Bioprinting for Substance Development.

Toxicological screening is crucial for safety assessment of compounds, i.e. chemicals and pharmaceuticals. In line with the paradigm shift in toxicology, in vitro tests based on human cells are thought to be a predictive alternative to the apical animal testing that is currently still the gold standard for hazard assessment. To produce human cell-based neural in vitro systems for neurotoxicity testing is a challenge, especially due to the complexity of the human brain. One issue that needs tackling is the generation of neuronal networks for compound testing that can be produced stably and reproducibly in a relative short period of time in a multi-well format. The so far established networks using e.g. embryonic or induced pluripotent stem cells have a high variability and take a very long time to establish.

Therefore, in an interdisciplinary approach, the 3D bioprinting technology shall be used to fabricate hydrogel-based neuronal networks based on human induced pluripotent stem cell (iPSC)-derived neurons and glia cells for neurotoxicity in vitro testing. These organoid structures are thought to mimic human in vivo neuronal functions and are thus of interest for industrial medium-throughput applications.

For this challenging project, we seek for a highly motivated individual who has experience either with hydrogel preparation/characterization, stem cells, tissue engineering, 3D cell culture, or molecule crosslinking techniques. Ideally students of Biochemistry or Biomedical Engineering, or others with expertise in the mentioned research fields are welcome. Knowledge in Neurosciences, fluorescence imaging, IT affinity, and previous working experiences with cell cultures is a plus. We expect a team player with an outstanding commitment and fun at work. We offer an interdisciplinary and industrially funded project in Applied Science, an intensive on-the-job training, and a stimulating working atmosphere. Starting date is from December 2018.

Please send your application as one PDF file incl. cover/motivation letter and your CV to:

 

IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH

Dr. rer. nat. Ines Lauria

Auf’m Hennekamp 50

40225 Düsseldorf

Ines.Lauria@IUF-Duesseldorf.de

Tierpflegerin/Tierpfleger in Forschung und Klinik

Zum nächstmöglichen Zeitpunkt suchen wir in der Tierhaltung des IUF eine/einen engagierte/n Tierpflegerin/Tierpfleger in Forschung und Klinik.

Ihr Aufgabengebiet:

  • Übernahme der tierpflegerischen Tätigkeiten in der Zucht und Haltung von transgenen Mäusen
  • Dokumentation nach gängigen tierschutzrechtlichen Anforderungen
  • Teilnahme und Unterstützung der tierexperimentellen Arbeiten (Maus und Ratte)
  • Materialvorbereitung und –pflege
  • Durchführung von Hygienemaßnahmen


Ihr Idealprofil:

  • Erfolgreich abgeschlossene Ausbildung zur/zum Tierpfleger/in Forschung und Klinik
  • Erfahrung in der Versorgung und Pflege von Nagern im Bereich Forschung ist von Vorteil
  • Bereitschaft zum Wochenenddienst
  • EDV-Kenntnisse
  • eigenständige und strukturierte Arbeitsweise
  • Teamfähigkeit, Belastbarkeit, Flexibilität und Zuverlässigkeit


Die Stelle ist zunächst auf 2 Jahre befristet, mit der Option auf unbefristete Weiterbeschäftigung. Das Arbeitsverhältnis richtet sich nach den Bestimmungen des Tarifvertrages für die Beschäftigten der Länder (TV-L). Die wöchentliche Arbeitszeit beträgt 39 Stunden und 50 Minuten. Teilzeitbeschäftigung ist möglich.

Bitte richten Sie Ihre vollständigen Bewerbungsunterlagen (Anschreiben, Lebenslauf, Zeugnisse) – unter Angabe des Aktenzeichens „Tierpflege“ in der Betreffzeile – per E-Mail an Bewerbung@IUF-Duesseldorf.de an:

IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH
VTH
Herrn Dr. Braun
Auf`m Hennekamp 50
40225 Düsseldorf

Per Post eingereichte Bewerbungsunterlagen werden nicht zurückgesandt. Unterlagen nicht berücksichtigter Bewerber/innen werden nach Abschluss des Verfahrens ordnungsgemäß vernichtet. Diskretion und die gewissenhafte Einhaltung von Sperrvermerken werden selbstverständlich zugesichert.

Tierpflegerin/Tierpfleger in Forschung und Klinik (unbefristet)

Zum nächstmöglichen Zeitpunkt suchen wir in der Tierhaltung des IUF eine/einen engagierte/n Tierpflegerin/Tierpfleger in Forschung und Klinik.

Ihr Aufgabengebiet:

  • Übernahme der tierpflegerischen Tätigkeiten in der Zucht und Haltung von transgenen Mäusen und Ratten
  • Verantwortung von züchterischen Maßnahmen transgener Mausstämme
  • Dokumentation nach gängigen tierschutzrechtlichen Anforderungen
  • Teilnahme und Unterstützung der tierexperimentellen Arbeiten (Maus und Ratte)
  • Mitarbeit in der Aus- und Weiterbildung von Auszubildenden und bei FELASA Weiterbildungen
  • Materialvorbereitung und –pflege
  • Durchführung von Hygienemaßnahmen


Ihr Idealprofil:

  • Erfolgreich abgeschlossene Ausbildung zur/zum Tierpfleger/in Forschung und Klinik
  • Erfahrung in der Versorgung und Pflege von Nagern insbesondere transgener Mäuse im Bereich Forschung
  • AdA-Schein
  • Bereitschaft zum Wochenenddienst
  • EDV-Kenntnisse
  • eigenständige und strukturierte Arbeitsweise
  • Teamfähigkeit, Belastbarkeit, Flexibilität und Zuverlässigkeit


Die Stelle ist unbefristet zu besetzen. Das Arbeitsverhältnis richtet sich nach den Bestimmungen des Tarifvertrages für die Beschäftigten der Länder (TV-L). Die wöchentliche Arbeitszeit beträgt 39 Stunden und 50 Minuten. Teilzeitbeschäftigung ist möglich.

Bitte richten Sie Ihre vollständigen Bewerbungsunterlagen (Anschreiben, Lebenslauf, Zeugnisse) – unter Angabe des Aktenzeichens „Tierpflege“ in der Betreffzeile – per E-Mail an Bewerbung@IUF-Duesseldorf.de an:

IUF – Leibniz-Institut für umweltmedizinische Forschung gGmbH
VTH
Herrn Dr. Braun
Auf`m Hennekamp 50
40225 Düsseldorf

Per Post eingereichte Bewerbungsunterlagen werden nicht zurückgesandt. Unterlagen nicht berücksichtigter Bewerber/innen werden nach Abschluss des Verfahrens ordnungsgemäß vernichtet. Diskretion und die gewissenhafte Einhaltung von Sperrvermerken werden selbstverständlich zugesichert.

Zurück